Hen egg white contains more than 40 kinds of proteins with concentrations reaching 100 mg/mL. Highly concentrated protein mixtures are common in the food industry, but the effects of a crowded environment containing salts on protein stability and aggregation have only been investigated using pure protein solutions. Here, we investigated the thermal aggregation of hen egg white protein (EWP) at ...

Numerous human diseases are associated with conformational change and aggregation of proteins, including Alzheimer’s, Parkinson’s, prion diseases (such as mad cow disease), familial amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease), Huntington’s, and type II (mature onset) diabetes. In many cases, it has been demonstrated that conformational change and aggregation can occur outside l...

Gold- and silver nanoparticles (Au NPs Ag NPs)-based colorimetric detection of specific analytes has attracted intense research interest is still in great demand. The majority Au NPs- NPs-based sensory reports have revealed that, during the analyte recognition, dispersed typically aggregated displayed color changes from wine-red to blue/purple yellow orange/brown, respectively. On other hand, o...

When particles undergo aggregation, very often they form structures that can be described with fractal geometry concepts. The spatial organization of the particles embedded in these aggregates, quantified by means of their fractal dimension, plays a key role in the clusters' diffusion and aggregation process. Fractal dimensions are typically known for some specific, ideal aggregation scenarios,...

Polyethylene glycol (PEG) is widely used to sterically stabilize liposomes and improve the pharmacokinetic profile of drugs, peptides and nanoparticles. Here we report that ammonium sulfate (AS) can evoke the aggregation of PEGylated vesicles in a concentration-dependent manner. Liposomes with 5mol% PEG were colloidally stable at AS concentrations up to 0.7mM, above which they precipitated and ...

Therapeutic administration of immunoglobulins (Ig) has the potential to precipitate thrombotic events. This phenomenon may be explained by red blood cell (RBC) aggregation, which can be potentiated by Ig. The contribution of plasma albumin and fibrinogen to Ig-induced RBC aggregation is unclear. We examined RBC aggregation in three settings: 1) patients receiving therapeutic infusions of Ig; 2)...

A discrete model for computer simulations of the clustering dynamics of Social Amoebae is presented. This model incorporates the wavelike propagation of extracellular signaling cAMP, the sporadic firing of cells at early stage of aggregation, the signal relaying as a response to stimulus, the inertia and purposeful random walk of the cell movement. A Monte Carlo simulation is run which shows th...

Modelling and analysis of dynamic geospatial phenomena has emerged as a major research topic within the GIS community. Although present representational and analytical apparatus to examine the dynamics of such phenomena is nascent at best, the issue is increasingly being considered as a major research priority in the GIS area [Yuan et al., 2004]. In this context, our research is concerned with ...