Nitrogen, one of the most abundant elements in nature, forms the highly stable N2 molecule in its elemental state. In contrast, polynitrogen compounds comprising only nitrogen atoms are rare, and no molecular crystal made of these compounds has been prepared. Here, we predict the existence of such a molecular solid, consisting of N8 molecules, that is metastable even at ambient pressure. In the...

Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. To evaluate long-term safety of N8-GP, 26- and 52-week tox...

BACKGROUND AND OBJECTIVE Stuttering is one of the most common speech disorders in adolescents than adults. Stuttering results in depression, anxiety, behavioral problem, social isolation and communication problems in daily life. Our objective was to determine the effect of Aerobic Exercises (AE) on stuttering. METHODS A quasi trail was conducted at National Institute of Rehabilitation Medicin...

The exercise paradox infers that, despite the well-established cardioprotective effects of repeated episodic exercise (training), the risk of acute atherothrombotic events may be transiently increased during and soon after an exercise bout. However, the acute impact of different exercise modalities on platelet function has not previously been addressed. We hypothesized that distinct modalities ...

The biologic fate of the [(3)H]PEG-moiety incorporated into N8-GP was evaluated based on single i.v. bolus doses to rats. Furthermore, the 40kDa [(3)H]PEG-moiety was given separately to rats by single i.v. bolus doses, to investigate if the pharmacokinetics were dose-dependent. For both compounds, plasma pharmacokinetics, distribution and excretion pathways were investigated, based on total rad...

BACKGROUND Physical inactivity is now a global non-communicable disease. Current recommendations from American College of Sports Medicine, American Heart Association and UK medical officers for physical activity are difficult to implement, due to time constraints and hence, they have less compliance. PURPOSE To compare Sprint Interval Training (SIT) and traditional aerobic exercise (AE) with ...

Objective: The aim of the present study was to examine the effectiveness of Acceptance and Commitment Therapy (ACT) combined with aerobic exercise (AE) on anxiety symptoms, insulin resistance (IR) and lipid profile in women with T2DMmellitus (T2DM). Materials and Methods: In the present study, 60 T2DM women with a mean age of 33.5 (± 3.52) years were selected from the patients who were referre...

Bone turnover is the cellular machinery responsible for bone integrity and strength and, in clinical setting, it assessed using markers (BTMs). Acute exercise can induce mechanical stress on which needed remodelling, but to date, there are conflicting results regards effects of varying stimuli BTMs. This systematic review examines acute aerobic, resistance impact exercises BTMs middle older-age...

Introduction: A decrease in respiratory functions (RF) and functional capacity (FC) may present as complications of intensive care unit (ICU) admission. Morbid obesity worsens these complications. Case: 31-year-old male patient with morbid came for pulmonary rehabilitation (PR) one week after hospitalization. He suffered from COVID-19 received 15 days mechanical ventilation. The goal PR was to ...

Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and overall brain and mental health. In particular, AE has a potent impact on promoting the function of the hippocampus and stimulating neuroplasticity. As the evidence-base rapidly builds, and given most of the supporting work can be readily translated from animal models to humans, the potential for AE to be ...