Melasma is a hyperpigmented dermatological condition common in females. Drugs such as steroids, cosmetics, and photosensitizing agents are known to cause melasma. We report here a case of an adult male with obsessive-compulsive disorder, receiving clomipramine, who developed melasma.

DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA DIAZINON Chemical Code # 198, SB 950-204, Tolerance # 00153 July 29, 1986 Revised 6/16/88, 2/17/89, 2/27/90, 12/28/93, 8/20/96, 7/21/98, 4/15/99 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, no ad...

BACKGROUND Adverse drug reactions (ADRs) vary from life-threatening anaphylaxis to minor common side-effects. OBJECTIVE To provide an overview on the assessment of ADRs. To discuss the features of what may be described as a 'reaction to a drug' in order to highlight those suggestive of allergy, side-effect or intolerance, and what implications this might have for the future use or avoidance o...

Dermographism, or skin writing, is the most common type of physical urticaria, manifesting as pruritic linear wheals and erythema secondary to minor trauma, such as rubbing or stroking the skin. This reaction in the superficial dermis occurs within seconds to minutes after mechanical irritation and typically resolves within 1 to 2 hours. Usually there are no associated systemic signs and sympto...