نتایج جستجو برای: adrenergic receptors adrb3

تعداد نتایج: 256242  

Journal: :Computational and Theoretical Chemistry 2021

The β2-adrenergic receptor, located in the prostate region, binds noradrenaline and can influence growth of tumors. removal Adrb2, gene for this halt tumor thus serve as an alternative to chemotherapy cancer treatment. Inhibition receptor may have similar effects. Comparison β2- (PDB ID: 5X7D) β1-adrenergic 2Y04) structures showed a conserved binding region on Chain A offset by approximately ei...

Journal: :Japanese journal of pharmacology 1993
S Shima

Characterization of adrenergic receptors in membranes from the rat seminal vesicle was studied by radioligand binding assay. Seminal vesicle membranes contained saturable and high affinity binding sites for the beta-adrenergic receptor antagonist 3H-dihydroalprenolol (3H-DHA) and for the alpha-adrenergic antagonist 3H-prazosin. The observed order of potency for adrenergic agonists in competing ...

2011
Barbara Szepietowska Wanling Zhu Owen Chan Adam Horblitt James Dziura Robert S. Sherwin

OBJECTIVE Norepinephrine is locally released into the ventromedial hypothalamus (VMH), a key brain glucose-sensing region in the response to hypoglycemia. As a result, this neurotransmitter may play a role in modulating counterregulatory responses. This study examines whether norepinephrine acts to promote glucose counterregulation via specific VMH β-adrenergic receptors (BAR). RESEARCH DESIG...

Journal: :Journal of cell science 1999
R H Moore A Tuffaha E E Millman W Dai H S Hall B F Dickey B J Knoll

During prolonged exposure to agonist, beta2-adrenergic receptors undergo downregulation, defined by the loss of radioligand binding sites. To determine the cellular basis for beta2-adrenergic receptor downregulation, we examined HEK293 cells stably expressing beta2-adrenergic receptors with an N-terminal epitope tag. Downregulation was blocked by leupeptin, a cysteine protease inhibitor, but no...

2014
Eduardo Gómez-Gómez Martín Efrén Ríos-Martínez Elena Margarita Castro-Rodríguez Mario Del-Toro-Equíhua Mario Ramírez-Flores Ivan Delgado-Enciso Ana Lilia Pérez-Huitimea Luz Margarita Baltazar-Rodríguez Gilberto Velasco-Pineda Jesús Muñiz-Murguía

Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism. CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their respective polymorphisms E531K and W64R have been identified as indicators of obesity in population studies. It is therefore important to understand the effect...

2005

ACTH “big ACTH”, 175 “little ACTH”, 175 Acetyl strophanthidin, radioimmunoassay, 221 Adenylate cyclase activity, measurement by radioimmunoas8ay, 312 beta-Adrenergic binding sites catecholamine assay vehicle, 259 heart muscle membrane fractions, 259 Adrenergic receptors, current concepts, 259 alpha-Adrenergic receptors, catecholamines, 261 beta-Adrenergic receptors, catecholamines, 261 Aldoster...

Journal: :Folia Endocrinologica Japonica 1994

2004
De-Pei Li Lindsay M. Atnip Shao-Rui Chen Hui-Lin Pan

Neurons in the paraventricular nucleus (PVN) that project to the brainstem and spinal cord are important for autonomic regulation. The excitability of pre-autonomic PVN neurons is controlled by the noradrenergic input from the brainstem. In this study, we determined the role of " 2 adrenergic receptors in the regulation of excitatory and inhibitory synaptic inputs to spinally projecting PVN neu...

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