Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They attach mono- or poly-ADP-ribose to targets using NAD+ as a substrate. Poly-ADP-ribosylation (PARylation) is central important functions PARP enzymes in DNA damage response nucleosome remodelling. Activation happens through binding via zinc fin...

Abstract In this pilot study, we proposed an algorithm to use thromboelastography platelet mapping (TEG-PM) as effective preoperative function assessment tool in coronary artery bypass graft surgery (CABG) reduce the transfusion requirement by determining timing of patients who are on dual antiplatelet therapy (DAPT). Total 15 elective CABG were receiving DAPT tested TEG-PM assay after 72 hours...

The analytic deep prior (ADP) approach was recently introduced for the theoretical analysis of image (DIP) methods with special network architectures. In this paper, we prove that ADP is in fact equivalent to classical variational Ivanov solving ill-posed inverse problems. Besides, propose a new variant which incorporates strategy early stopping into model. For both variants, show how regulariz...

Based on the structure of natural product andrographolide, a series novel 12-quinoline substituted derivatives 9 were designed and synthesized. In preliminary biological evaluation, these synthesized compounds showed prominent anti-platelet aggregation activities in response to thrombin adenosine diphosphate (ADP) agonists. Among them, compound 9o (inhibition rate 55.73%, IC50 0.36 µM/L) had hi...

Background: Patients undergoing cardiac surgery are at increased risk of bleeding due to multifactorial coagulopathies. In the present study, we aimed at investigating the changes in platelet count and function during and after surgery as well as determining the association of the platelet dysfunction with bleeding and transfusion requirements in these patients.    Methods: A total o...

The study analyzed farm management extension services (FMESs) performed by the extension agents of Agricultural Development Projects in South West Nigeria. Study representatives were sampled randomly from Oyo ADP, Osun ADP and Ekiti ADP, making a 50% representation of the South-West. A proportionate sample of 80% of the total of the extension agents in each of the 3 case studies was randomly se...

The silent information regulator 2 (Sir2) family of NAD-dependent N-acetyl-protein deacetylases participates in the regulation of gene silencing, chromatin structure, and longevity. In the Sir2-catalyzed reaction, the acetyl moiety of N-acetyl-histone is transferred to the ADP-ribose of NAD, yielding O-acetyl-ADP-ribose and nicotinamide. We hypothesized that, if O-acetyl-ADP-ribose were an impo...

We study the nature (constructive versus non-constructive) and issue of real-valued representability social welfare orders, on set infinite utility streams, satisfying anonymity asymptotic density-one Pareto axioms. characterize existence representable constructive orders (fulfilling aforementioned axioms) in terms easily verifiable conditions feasible one-period utilities, denoted by Y ⊂ R : a...

The transfer of ADP–ribose (ADPr) from nicotinamide adenine dinucleotide (NAD+) to target proteins is mediated by a class human diphtheria toxin-like ADP-ribosyltransferases (ARTDs; previously referred as poly-ADP–ribose polymerases or PARPs) and the removal ADPr catalyzed family glycohydrolases. Although thousands potential modification sites have been identified using high-throughput mass-spe...