OBJECTIVE In rheumatoid arthritis (RA), endothelial dysfunction caused by the inflammatory process increases the risk of cardiovascular disease. Asymmetric Dimethylarginine (ADMA) leads to vascular dysfunction, whereas atherosclerosis and increased ADMA is associated with cardiovascular disease risk factors. Flow-mediated Dilation (FMD) is a radiological method to demonstrate endothelial dysfun...

Asymmetrical dimethylarginine (ADMA) is thought to be an endogenous regulator of arteriolar tone by inhibiting NO synthase. However, our previous studies showed that, in isolated arterioles, ADMA induced superoxide production as well. Thus, the mechanisms by which ADMA affects arteriolar tone remain obscure. We hypothesized that ADMA, by activating NAD(P)H oxidase, increases superoxide producti...

BACKGROUND The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way int...

Hypoxia-induced and high altitude pulmonary hypertension are a major problem in the mountain areas of the world. The asymmetric methylarginines (ADMA) inhibit nitric oxide (NO) synthesis by competing with L-arginine, and high levels of plasma ADMA predict adverse outcomes in pulmonary hypertension. However, little is known about the regulation of the ADMA-NO pathway in animals adapted to high a...

BACKGROUND Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). Plasma levels of ADMA are elevated in individuals with hypercholesterolemia or atherosclerosis. We postulated that reduced degradation of ADMA may play a role in the accumulation of ADMA in these individuals. Accordingly, we studied the effects of oxidized LDL (oxLDL) or tumor necrosis facto...

Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and due to VSMCs phenotype change. ADMA activates Rho/ROCK signal pathway that interpreted by the eleva...

Asymmetric Dimethylarginine and Hypertension in Cerebral Small Vessel Disease To the Editor: We read with great interest the recent article by Khan et al1 dealing with the relationship between the endogenous nitric oxide (NO) synthase inhibitor, asymmetric dimethylarginine (ADMA), and cerebral small vessel disease (SVD). The results of their study demonstrated that the plasma ADMA levels were e...

Background: Anti-Tumor Necrosis Factor (TNF)-α therapy seems to improve vascular pathology in patients with inflammatory arthropathies such as rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Asymmetric dimethylarginine (ADMA) competes with Larginine as a substrate for nitric oxide synthase (NOS) and the L-arginine/ADMA ratio is important for modulation of the NOS activ...

POLSKIE ARCHIWUM MEDYCYNY WEWNĘTRZNEJ 2013; 123 (10) To the Editor We read the article by Szpak et al.1 with interest. The authors investigated whether active or passive tobacco smoking may affect en‐ dothelial dysfunction markers such as asymme‐ tric dimethylarginine (ADMA), thrombomodulin (TM), plasminogen activator inhibitor‐1 (PAI‐1), and cotinine levels in patients with advanced co‐ ronary...

Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), impairs the beneficial effect of NO. The predictive value of ADMA for all-cause mortality remains controversial, though it is important in the development of cardiovascular disease (CVD) and progression to dialysis in renal disease. This systematic review and meta-analysis was conducted to investigate ...