نتایج جستجو برای: adenoviruses

تعداد نتایج: 6905  

Journal: :Journal of General Virology 1995

Journal: :Cold Spring Harbor perspectives in biology 2013
Rob C Hoeben Taco G Uil

Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basi...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Christopher Y Chen Julien S Senac Eric A Weaver Shannon M May Diane F Jelinek Philip Greipp Thomas Witzig Michael A Barry

PURPOSE Oncolytic viruses are self-amplifying anticancer agents that make use of the natural ability of viruses to kill cells. Adenovirus serotype 5 (Ad5) has been extensively tested against solid cancers, but less so against B-cell cancers because these cells do not generally express the coxsackie and adenoviral receptor (CAR). To determine whether other adenoviruses might have better potency,...

2011
Christopher Y. Chen Julien S. Senac Eric A. Weaver Shannon M. May Diane F. Jelinek Philip Greipp Thomas Witzig Michael A. Barry

Purpose: Oncolytic viruses are self-amplifying anticancer agents that make use of the natural ability of viruses to kill cells. Adenovirus serotype 5 (Ad5) has been extensively tested against solid cancers, but less so against B-cell cancers because these cells do not generally express the coxsackie and adenoviral receptor (CAR). To determine whether other adenoviruses might have better potency...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Lotta Kangasniemi Tuula Kiviluoto Anna Kanerva Mari Raki Tuuli Ranki Merja Sarkioja Hongju Wu Frank Marini Krister Höckerstedt Helena Isoniemi Henrik Alfthan Ulf-Håkan Stenman David T Curiel Akseli Hemminki

PURPOSE Metastatic gastric cancer remains a common and devastating disease without curative treatment. Recent proof-of-concept clinical trials have validated gene therapy with adenoviruses as an effective and safe modality for the treatment of cancer. However, expression of the primary coxsackie-adenovirus receptor is variable in advanced cancers, and therefore, the use of heterologous receptor...

Journal: :Gut 2000
T Nakatani S Kuriyama K Tominaga T Tsujimoto A Mitoro M Yamazaki H Tsujinoue H Yoshiji S Nagao H Fukui

BACKGROUND When recombinant adenoviruses are infused directly into the circulation, transgene expression is almost completely restricted to the liver. AIMS Efficiency and safety of adenovirus mediated gene transfer into damaged livers were examined in mice with liver cirrhosis or fulminant hepatitis. METHODS Liver cirrhosis and fulminant hepatitis were induced by intraperitoneal administrat...

2006
Zhiquan Xiang Yan Li Ann Cun Wei Yang Susan Ellenberg William M. Switzer Marcia L. Kalish Hildegund C.J. Ertl

Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses. Antibodies were more common in humans residing in sub-Saharan Africa than in humans living in the United States or Thailand. This finding suggests cross-species transmission of chimpanzee adenoviruses.

Journal: :Current cancer drug targets 2007
Youssef Jounaidi Joshua C Doloff David J Waxman

Replication-conditional, oncolytic adenoviruses are emerging as powerful tools in the warfare on cancer. The ability to modify cell-specific infectivity or tissue-specific replication machinery, as well as the possibility of modifying viral-cellular protein interactions with cellular checkpoint regulators are emerging as new trends in the design of safer and more effective adenoviruses. The int...

Journal: :Journal of virology 1998
P Pring-Akerblom A Heim F E Trijssenaar

The adenovirus fiber mediates the agglutination of erythrocytes. Based on differential hemagglutinating properties, subgenus D adenoviruses can be subdivided into clusters DI, DII, and DIII. While subgenus DI adenoviruses agglutinate rat and human erythrocytes, DII adenoviruses simply agglutinate rat erythrocytes and DIII adenoviruses display no or only weak rat erythrocyte agglutination. Amino...

Journal: :Journal of virology 2005
Anjan Purkayastha Susan E Ditty Jing Su John McGraw Ted L Hadfield Clark Tibbetts Donald Seto

Human adenovirus serotype 4 (HAdV-4) is a reemerging viral pathogenic agent implicated in epidemic outbreaks of acute respiratory disease (ARD). This report presents a genomic and bioinformatics analysis of the prototype 35,990-nucleotide genome (GenBank accession no. AY594253). Intriguingly, the genome analysis suggests a closer phylogenetic relationship with the chimpanzee adenoviruses (simia...

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