نتایج جستجو برای: adenosine receptors
تعداد نتایج: 307548 فیلتر نتایج به سال:
Although very common, the precise mechanisms that explain symptomatology of neuroendocrine syncope (NES) remain poorly understood. This disease, which can be incapacitating, manifests itself as a drop in blood pressure secondary to vasodilation and/or extreme slowing heart rate. As studies continue, involvement adenosinergic system is becoming increasingly evident. Adenosine, an ATP derivative,...
Adenosine receptors are present on most cells and organs, yet, although the physiological effects of adenosine were first described over 60 years ago, the potential therapeutic uses of adenosine have only been recognized and realized recently. A decade ago the potent anti-inflammatory effects of adenosine were first described; adenosine, acting at specific A2 receptors, inhibits some, but not a...
Adenosine receptors (ARs) are being explored to generate non-opioid pain therapeutics. Vanilloid compounds, curcumin, capsaicin, and vanillin possess antinociceptive properties through their interactions with the transient receptor potential channel family. However, binding adenosine has not been well studied. The hypothesis in this study was that a vanilloid compound, cis-trans curcumin (CTCUR...
Fatty liver is commonly associated with alcohol ingestion and abuse. While the molecular pathogenesis of these fatty changes is well understood, the biochemical and pharmacological mechanisms by which ethanol stimulates these molecular changes remain unknown. During ethanol metabolism, adenosine is generated by the enzyme ecto-5'-nucleotidase, and adenosine production and adenosine receptor act...
Dopamine, by activating dopamine D1-type receptors, and adenosine, by activating adenosine A(2A) receptors, stimulate phosphorylation of DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of M(r) 32,000) at Thr-34. In this study, we investigated the effect of metabotropic glutamate (mGlu) receptors on DARPP-32 phosphorylation at Thr-34 in neostriatal slices. A broad-spectrum mGlu receptor ag...
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