background the physiological link between ghrelin and growth hormone (gh) has not yet been fully clarified. furthermore, the existence of a negative feedback mechanism between growth hormone–insulin-like growth factor (gh–igf)-i axis and ghrelin and the influence of amino acids on ghrelin secretion in children remain matters of debate. objectives to understand the regulation of ghrelin secretio...

The reason for high altitude anorexia is unclear but could involve alterations in the appetite hormones ghrelin and peptide YY (PYY). This study examined the effect of resting and exercising in hypoxia (12.7% O(2); ∼4,000 m) on appetite, energy intake, and plasma concentrations of acylated ghrelin and PYY. Ten healthy males completed four, 7-h trials in an environmental chamber in a random orde...

BACKGROUND Ghrelin, a 28 amino acid peptide, is effective in control of appetite and body weight. Acylated ghrelin peptide is the active form of this peptide which plays a major role in the body's energy balance. OBJECTIVES This study aimed to investigate the possible effect (s) of intensive resistance exercise on acylated ghrelin, growth hormone, glucose, insulin, and cortisol plasma levels....

Although it is known that urocortin 1 (UCN) acts on both corticotropin-releasing factor receptors (CRF(1) and CRF(2)), the mechanisms underlying UCN-induced anorexia remain unclear. In contrast, ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, stimulates food intake. In the present study, we examined the effects of CRF(1) and CRF(2) receptor antagonists (CRF(1)a and ...

Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and GH secretion via interactions with the GH secretagogue type 1a receptor (GHS-R1a), the functionally active form of the GHS-R. Ghrelin molecules exist in the stomach and hypothalamus as two major endogenous forms, a form acylated at serine 3 (ghrelin) and a des-acylated form (des-acyl ghrelin). Acylation i...

conclusions urinary ghrelin concentration was lower before treatment of uti and significantly increased after cessation of inflammation. further studies are required for more definite results. patients and methods this study was performed on 40 hospitalized children with uti at mofid children’s hospital during years 2013 to 2014. ghrelin and creatinine were measured before and after treatment. ...

Ghrelin, an acylated peptide serving as an endogenous ligand for GH secretagogue receptor (GHS-R), was originally isolated from rat and human stomach. In this study, we report the critical role of maternal ghrelin in fetal development. High levels of ghrelin receptor (GHS-R) mRNA were detected in various peripheral fetal tissues beginning at embryonic d 14 and lasting until birth. Fetal GHS-R e...

BACKGROUND/AIMS Due to risk of morbidity and mortality, various tests and scoring systems used in the assessment of the diagnosis and severity of acute pancreatitis disease are gaining more importance every day. Most of the current scoring systems, validated by various parameters, have a sophisticated and complex structure. Research is ongoing to establish a method to diagnose the disease and d...

Ghrelin is a 28 amino acid peptide predominantly produced by the stomach that has been discovered to be a natural ligand of the orphan growth hormone (GH) secretagogue (GHS) receptor (GHS-R) type 1a. Like synthetic GHS, ghrelin possesses a strong GH-releasing effect provided that the molecule is acylated in serine3 and it is thought to be a natural GHS of major importance in the control of soma...

An intensive consecutive high-volume training camp may induce appetite loss in athletes. Therefore, this study aimed to investigate the changes in stress and appetite responses in male power-trained athletes during an intensive training camp. The measurements at Day 2 and at the end of a 9-day intensive training camp (Camp1 and Camp2, respectively) were compared with those of the resting period...