tlte usual manifestation of acute promyelocyte leukemia is hemorrliagic tendency hut thrombotic manifestations may dominate the clinical picture. we report a patient with promyelocyte leukemia which presented as thrombotic cerebrovascular accident and responded to all-transretionic acid and chemotherapy.

background and purpose: leukemia is the most prevalent type of cancer in children and its prognostic factors vary in different geographic locations. the aim of this study was to estimate the 5 years survival rate of children suffering from leukemia in kerman, iran and to investigate the factors which might influence it. materials and methods: this was a cohort study conducted on patients with a...

abstractintroduction: the role of breast-feeding in protection against childhood acute leukemia is uncertain. in this study, we tested the hypothesis that breast-feeding decreases the risk of 300 patients we investigated childhood acute leukemia. materials and methods: in a case control study, we inrestigated 300 patients, aged 2±13 years, with acute leukemia, as well as 300 controls, individua...

introduction: acute leukemia is the most common malignancy in children and acute lymphoblastic leukemia (all) accounts for 75% of acute leukemia cases. new treatment protocols have resulted in complete remission rates up to nearly 100% in children with acute lymphoblastic leukemia. today, one of the most important prognostic factors in acute lymphoblastic leukemia is intensity of the treatment....

recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. to evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. the polymorphisms of genes encoding carcinogen-metabolizing ...

background : we conducted the present study to investigate the frequency of prothrombin g20210a mutation among acute lymphoblastic leukemia patients and healthy individuals from western iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population. methods : the studied groups consisted of 92 children with acute lymphoblastic le...

introduction: oral candidosis is among the find-ings of acute leukemia. the aim of this study was to evaluate the changes in the intensity of c.albicans, before treatment and at the induc-tion phase. materials and methods: twelve patients with acute lymphoblastic leukemia (all) aged 2-14 years enrolled in study. whole saliva samples were obtained and cultured to determine the mean count of c.al...

background: mucositis is a complex inflammatory response of the digestive system mucous membrane and it is also one of the most common painful side effects following chemotherapy in children with carcinoma. developing to mucositis affects the patient's life severely and can lead to long – term hospitalization.therefore, this study was conducted to evaluate the effect of chamomile mouthwash on t...

background: acute lymphoblastic leukemia (all) is the most common subtype of childhood cancer. chromosomal ab­normality, specially the replacement of chromosomal material is one of the main reasons in generating leukemia, wherein the kind of translocation play a key role in managing the remedy. the goal of the present study was to develop a reliable, rapid, and cost effective method to detect t...

introduction: osteoprotegerin (opg), a soluble decoy receptor secreted by osteoblasts, binds rank-l, preventing stimulation of osteoclastogenesis. in the present study we aimed to investigate the impact of opg variants and susceptibility to childhood acute lymphocytic leukemia (all) in a sample of iranian population. methods: this case-control study was done on 98 all and 124 healthy children. ...