In the present study we utilized a semisolid culture system with feeder cells and enriched media to evaluate the growth of acute leukemia associated with the 4;11 chromosomal translocation. We compared growth of t(4;11) leukemia to typical acute nonlymphocytic leukemia (ANL) and acute lymphocytic leukemia (ALL). The two cases of t(4;11) leukemia tested exhibited the highest cloning efficiency o...

abstract objective the great majority of patients with childhood leukemia become long-term survivors. they treated with chemotherapy and prophylactic central nervous system (cns) irradiation. the aim of this cross-sectional study was to evaluate effect of the long-term toxicity in all survivors, and possible effects of this treatment on their intellectual in compare with their sibling. material...

Genome-editing systems such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology have uncovered new opportunities to model diseases chronic lymphocytic leukemia. CRISPR/Cas9 is an important means of advancing functional studies Chronic Lymphocytic Leukemia (CLL) through the incorporation, elimination and modification somatic mutations in CLL models.

Cytidine triphosphate synthetase (CTP synthetase) activity was measured in extracts from normal and malignant lymphoid cells. A range of enzyme activities was found in the majority of the lymphoproliferative disorders examined, with acute lymphocytic leukemia, nodular poorly differentiated lymphocytic lymphoma, and diffuse histiocytic (large cell) lymphoma (DHL) types exhibiting the widest rang...

Nonhuman primate antisera defining leukemia-associ ated and normal Tand B-lymphocyte-associated anti gens were used to characterize serologically the cells from acute myelomonocytic leukemia (AMML) and chronic myelogenous leukemia patients in blast crisis (CML-BC). Earlier studies demonstrated that nonhuman primate an tisera to chronic lymphocytic leukemia, acute myelogen ous leukemia, and chro...

Abbreviations: acute lymphoblastic leukemias, (ALLs); acute myeloid leukemia, (AML); arsenic trioxide, (ATO); B-cell chronic lymphocytic leukemia, (B-CLL); blast crisis, (BC); chronic lymphocytic leukemias, (CLL); CML-Acceleration Phase/Blast Crisis, (CML/AP/BC); CML-Bone Marrow Transplantation patients, (CML-BMT); CML-Chronic Phase patients, (CML/CP); DNA binding domain, (DBD); dominant-negati...