INTRODUCTION This study is aimed to assess the prevalence and characteristics of head and neck lymphoma in a defined group of an Iranian population. MATERIALS AND METHODS In this retrospective study, 126,450 biopsy reports from two referral Pathology Departments, (Tehran, the capital of Iran) were evaluated. In cases with head and neck lymphoma, other variables such as age, sex, specific loca...

Although preservation of the spleen following abdominal trauma and spleen-preserving surgical procedures have become gold standards, about 22,000 splenectomies are still conducted annually in the USA. Infections, mostly by encapsulated organisms, are the most well-known complications following splenectomy. Recently, thrombosis and cancer have become recognized as potential adverse outcomes post...

We have shown previously that cancer/testis (CT) antigen, CT45, is expressed in various epithelial cancers at a frequency of <5% to approximately 35%. In this study, the protein expression of CT45 was examined in non-Hodgkin B-cell lymphomas and classical Hodgkin lymphoma by immunohistochemical analysis. Serological response to CT45 was also evaluated by ELISA using CT45 recombinant protein and...

fuzzy expert systems are one of the most practical intelligent models with the high potential for managing uncertainty associated to the medical diagnosis. in this paper, a fuzzy inference system (fis) for diagnosing of acute lymphocytic leukemia in children has been introduced. the fuzzy expert system applies mamdani reasoning model that has high interpretability to explain system results to e...

Tumor necrosis factor-α-inducible protein-2 (TNFAIP2) is a protein upregulated in cultured cells treated with tumor necrosis factor α (TNF), but its expression in normal and neoplastic tissues remains largely unknown. Here, we use standard immunohistochemical techniques to demonstrate that TNFAIP2 is normally expressed by follicular dendritic cells, interdigitating dendritic cells, and macropha...

A monoclonal antibody specific for a common acute lymphoblastic leukemia (ALL) antigen has been generated and char acterized. This antibody (J-5) is reactive with leukemic cells from most patients with non-T-cell ALL and some patients with chronic myelocytic leukemia in blast crisis. J-5 antibody is not reactive with leukemic cells from patients with either T-cell ALL, chronic lymphocytic leuke...

Do cy-togenetic abnormalities precede morphologic abnormalities in a developing malignant condition? Eur J Haematol 2007;78: 152-6. 4. Wong KF, Kwong YL. Isochromosome 8q is a marker of secondary acute myeloid leukemia. Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis. et al. 6q deletion detected by fluorescence in situ hybridization using bacterial artificia...

Matrix metalloproteinases (MMPs) are a large family of zinc-containing proteases several functions of the MMPs were identified in various systems such as cell migration/invasion, apopto-sis/cell survival, and angiogenesis (1). Besides, MMP-2 and MMP-9 have important implications in the progression and invasiveness of several hematological malignancies, including Hodgkin lymphomas (HL), malignan...

Donor lymphocyte infusions (DLIs) induce potent graft versus tumor (GVT) effects for relapsed chronic myelogenous leukemia (CML) after allogeneic stem cell transplantation (SCT) but are disappointing for other diseases. Disease resistance can occur if donor T cells are not appropriately activated in vivo. Ex vivo T-cell activation might overcome diseaseinduced anergy and augment GVT activity. W...