Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-threatening condition and thus carries a considerable risk of morbidity. The aetiology of the condition is autoimmune in nature with the predominant involvement of CD4(+) T cells. However, ...

PURPOSE Myeloid dendritic cells (mDCs) play an important role in autoimmune diseases. However, the role of blood CD1c(+) myeloid dendritic cells 1 (mDC1s), the subset of human blood mDCs, is not well understood in noninfectious uveitis. METHODS Fresh peripheral blood samples from human noninfectious uveitis patients (n = 32) and healthy controls (HCs) (n = 64) were stained with FITC-Lineage 1...

PURPOSE To investigate the clinical features of secondary glaucoma associated with uveitis. METHODS The subjects of the study were 1,099 patients with uveitis (1,604 eyes) treated at the Miyata Eye Hospital, Miyakonojo, Miyazaki, between October 1974 and January 2000. The intraocular pressure (IOP) and clinical data were analyzed retrospectively. Secondary glaucoma was diagnosed in the patien...

AIM To investigate T-bet mRNA and protein expression on peripheral blood mononuclear cells (PBMC) in patients with Behçet's disease with active uveitis. METHODS Blood samples were taken from 24 patients with Behçet's disease who had active uveitis and 16 healthy individuals. PBMC were subjected to analysis of T-bet mRNA and protein expression using semiquantitative reverse transcriptase-polym...

Background: Cataract surgery lens implantation is the most common eye surgery that good quality of operation can help good visual outcome. One of the most common complication following cataract surgery is uveitis that usualy occur in first few weeks after operation. The aim of the present study was to compare the incidence of the post operative uveitis between viscoelastic substance and air in...

purpose: to characterize keratic precipitate (kp) morphology in different forms of uveitis. methods: one hundred and twenty nine eyes of 93 patients with different forms of uveitis underwent confocal scan and the morphology of kps were determined. differences in kp morphologies among different uveitic groups were evaluated.  results: age ranged from 14 to 67 years (mean: 32.5±11.2) and 58 cases...

METHODS. Ocular fluid samples were collected from patients with active and inactive uveitis, as well as from control subjects without uveitis. The sTNF-Rs and TNFlevels were measured by enzyme-linked immunosorbent assay (ELISA). T-cell clones (TCCs) were established from intraocular infiltrating cells, and the TCCs were cocultured with recombinant sTNF-Rs or TNF. The supernatants were measured ...

PURPOSE Evaluation of peripheral retinal vascular changes in anterior uveitis using ultra-wide-field fluorescein angiography. DESIGN A prospective, observational study of a case series of patients diagnosed with anterior uveitis. METHODS SETTING Clinical observation at an academic medical center. Patient or Study Population: A total of 65 eyes of 33 patients corresponded with the researc...

AIMS To investigate the manifestations and severity of uveitis in children and to identify the risk and specific causes of blindness in this population. METHODS Retrospective study of data of 123 consecutive patients examined with active uveitis and the onset of ocular disease before the age of 16 years. Numerous variables were assessed including age and sex distribution, laboratory data, the...