Introduction: Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most pressing problems in pharmaceutical R&D, with as many as 90% of new API candidates in this category (Lobmann et al., 2013). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs (Zimmermann et al., 2009), which may limit their bioav...

S-[(4-chlorophenyl) methyl]diethylcarbamothioate General information This document reviews the environmental fate and environmental effects of the thiocarbamate herbicide, thiobencarb {S–[(4-chlorophenyl) methyl] diethylcarbamothioate (C 12 H 16 ClNOS)}. Thiobencarb, also referred to as benthiocarb was developed by Kumiai Chem. Ind. Co. Ltd and introduced in the market in 1970 (Ishikawa, 1981)....

The crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates two independent molecules form I obtained for first time. dimorphism convincingly demonstrates conformational versatility benzylthiouracil molecule. It has established through calorimetric studies that low-temperature II transforms endothermically (?II?IH = 5.6(1...

Controlled-release herbicide formulations have been shown to decrease the leaching potential of several herbicides under laboratory and Ðeld conditions. The utility and efficacy of these formulations may be improved by combining several herbicides and a fertilizer source in a single formulation. The objective of these studies was to develop granular alginate formulations that were composed of a...

High efficiency, cost effectiveness and short run time are the basic requirements of high-speed chromatographic separations. To fulfill these requirements, an advanced separation technique, ultraperformance liquid chromatography (UPLC), has shown promising developments. A rapid, specific, sensitive, and precise reverse-phase UPLC method was developed for the determination of antiparkinson drug ...

Hexazinone C3-cyc1ohexyl-6-(dimethylamino)-l-methyl-1,3,5-triazine-2,4(1~, 3H)-dionel in Z-cc pellets (10% active ingredient) was applied at rates of 0, 2, 4, and 8 pounds of active ingredient per acre for site preparation on clay soil in a randomized experiment in May 1980. Loblolly pine seedlings planted to the site in January 1981 were measured for diameter 3 inches above the ground, height,...

Product % Label Rate Active ingredient Paclobutrazol ounces/1,000 sq.ft . Paclobutrazol/Acre Andersons TGR (Turf Growth Regulator) and Turf Enhancer formulations are effective tools for reducing existing Poa annua in turf Paclobutrazol, the active ingredient in TGR and Turf Enhancer, is a root-absorbed gibberillic acid inhibitor. Since paclobutrazol is a growth regulator, you will see a differe...

The efficacy of 9 repellents (8 commercial repellents and one product under development) was evaluated on the skin at dosages of 0.65 and 1.7 mg of product/cm2, the latter dosage being the industrial standard for deet based repellents. The repellents were applied to the arm or lower leg of a human subject and tested against Anopheles stephensi in a cage or flying freely in a mosquito-proof room...