We investigated the possible use of acrylic cement containing chemotherapeutic drugs in the treatment of malignant lesions in bone. The diffusion of methotrexate (MTX) from methylpolymethacrylate implants was studied in vitro: polymerisation of the cement did not destroy the drug; liberation began immediately and about 10% was released by 18 hours. Some release continued for as long as six mont...

context this study aimed to provide an overview of the literature on the radiopacity of dental materials in order to emphasize its importance. evidence acquisition english-language literature was investigated using manual and electronic searches for the terms “radiopacity,” “dental material,” “cement,” “composite,” “ceramic,” “endodontic root canal sealer,” “bone graft,” and “acrylic resin” in ...

Local antibiotic delivery with antibiotic loaded acrylic bone cement has been used extensively in the management of chronic osteomyelitis and implant related infections. It is considered the gold standard for treatment of musculoskeletal infections (Nelson, 2004; Hanssen, 2005; Samuel et al., 2010). The critical factors in the treatment of any orthopaedic infection are adequate surgical debride...

Introduction Over the past years, in order to anchor a prosthetic component to bone, different cements based on selfpolymerizing poly (methyl methacrylate) (PMMA) have been widely used as commercial synthetic biomaterials. The aim of this study was to evaluate the influence of a PMMA-based bone cement (Palamed® G40) on the viscoelastic behaviour of spongy bone from proximal human tibial epiphys...

The efficacy of locally implanted antibiotic-calcium hydroxyapatite ceramic composites was investigated for the treatment of experimentally produced, implantrelated osteomyelitis in rats. High concentrations of antibiotics were detected at the site of infection and bacteria were eradicated without removal of the metal implants. Parenteral antibiotics and surgical debridement, alone or in combin...

I . Cement-bone interface histology 60 II . Acrylic bone cement and the exotherm 61 III . Radiographic analysis of interfaces in total hip replacement 63 IV. Interface biomechanics in total hip replacement 63 V. Radiographic analysis of interfaces in total knee replacement 65 VI . Interface biomechanics in total knee replacement 65 VII . Biomaterials interface biomechanics 66 VIII . Ceramic/bon...

Acrylic bone cement has been an essential non-metallic implant used as fixing agent in the cemented total joint arthroplasty (THA). However, the currently available materials based mainly on polymethylmethacrylate (PMMA) still encounter certain limitations, such as time-consuming polymerization, thermal and chemical necrosis and troublesome revision procedure. Here from an alternative way, we p...

Composite bone cements were formulated with bioactive glass (MgO--SiO(2)--3CaO. P(2)O(5)) as the filler and hydrophilic matrix. The matrix was composed of a starch/cellulose acetate blend (SCA) as the solid component and a mixture of methylmethacrylate/acrylic acid (MMA/AA) as the liquid component. The curing parameters, mechanical properties, and bioactive behavior of these composite cements w...