نتایج جستجو برای: acridines
تعداد نتایج: 1743 فیلتر نتایج به سال:
Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by competitive dialysis and compared with the anti-proliferative activities. While inactive acridine derivatives showed high selectivity for G-qu...
MONOFUNCTIONAL quinacrine mustard, 2-methoxy-6-chloro-9(3[ethyl2-chloroethyl] aminopropylamino) acridine dihydrochloride, ICR-170*, consists of two portions: an acridine ring and an alkylating mustard. The complex chemical structure of PCR-170 suggests that mutations could be produced by several different mechanisms. If the nitrogen mustard component of the molecule is the effective part of the...
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