Oral and topical antibiotics are commonly prescribed in dermatology to treat infectious skin disorders and inflammatory dermatoses. Prescribing data from 1999 to 2003 indicate that dermatologists write approximately 9 million oral antibiotic prescriptions annually, with tetracycline agents accounting for 65% and cephalosporins 10% of the total. The widespread use of oral tetracyclines relates p...

INTRODUCTION Autosomal dominant chronic mucocutaneous candidiasis (CMC) without endocrinopathy (OMIM 114580) is a well-described entity. The associations recorded with this disorder to date are intercellular adhesion molecule-1 (ICAM-1) deficiency and hyper-immunoglobulin E syndrome. CLINICAL PICTURE We report a new association in a family (mother and nonidentical twin sons) where acne rosace...

Abstract Acne rosacea is a common skin condition that affects people with Fitzpatrick types I–III and characterized by flushing, erythema, telangiectasia, pustules, papules phyma (Jansen T. Clinical presentations classification of rosacea. Ann Dermatol Venereol 2011; 138:3). This has been around for centuries referred to in literature art throughout history. The earliest reference acne can be t...

Clindamycin is a macrolide antibiotic that has been used orally and topically in the treatment of acne vulgaris. Unfortunately, oral administration is associated with pseudomembranous colitis in up to 10% of patients; consequently, it is no longer a generally accepted form of acne therapy. Topical application is an effective, safer alternative. Topical formulations may be extemporaneously prepa...

Probiotics are live micro-organisms that provide a health benefit to the host. The role of probiotics in the management of disease, as well as immune modification, has recently experienced a renewed interest in society, as probiotics can be found in products ranging from yogurt to facial creams. In this article, we discuss the role of probiotics in the development of the immune system, the trea...

CMAJ • APRIL 19, 2011 • 183(7) © 2011 Canadian Medical Association or its licensors E430 Acne vulgaris has a substantial impact on a patient’s quality of life, affecting both self-esteem and psychosocial development.1 Patients and physicians are faced with many over-the-counter and prescription acne treatments, and choosing the most effective therapy can be confusing. In this article, we outlin...

Retinoids are routinely used in dermatology for various clinical entities including acne vulgaris, rosacea, hypertrophic scars, strie distensae, psoriasis, disorders of dyskeratinization, cancer prevention and other chronic hyperkeratotic disorders. Oral acitretin therapy is effective in the treatment of psoriasis normalizing cellular differentiation and maturation but clinical side-effects are...

Indian J Dermatol Venereol Leprol | May-June 2010 | Vol 76 | Issue 3 syndrome[3] and slowing of linear growth[4] due to systemic absorption has been reported in infants and children with TC use, mainly on the diaper region. However, non-reversible adrenal insufficiency has not been reported. Older children and teenagers using TC on the face are more prone to develop steroid acne, rosacea or per...

methylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride hemiethanol hemihydrate (Fig. 1), is one of the tetracycline derivatives, which has a wide range of antibacterial activities. DOX is frequently used to treat chronic prostatitis, sinusitis, syphilis, chlamydia, pelvic inflammatory disease, acne, rosacea, and rickettsia...