Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoi...

Seven cases of this rare variant of breast carcinoma have been described in three previous publications. This paper describes an additional case, the first following chemotherapy, which in addition had an unfavourable prognosis. It also describes alterations in cell morphology, immunohistochemistry, and ultrastructure following chemotherapy.

Rationale:Acinic cell carcinoma (AcCC) of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. Patient concerns: A 52-year-old woman presented to the hospital with a palpable mass over the upper outer quadrant of the right breast. Diagnoses:Physical examination revealed an irregular mass in the lateral upper quadrant of the left breast,...

Objective: To investigate the clinicopathological, therapeutic, and survival data on pediatric major salivary gland cancers. Materials Methods: National Cancer Database (NCDB) query from 2004 to 2018. Results: In total, 967 cases of individuals under age 21 were identified. Most cancers affected parotid (86%). Mucoepidermoid carcinoma (41.3%) acinic cell adenocarcinoma (33.6%) most common. Tumo...

Mammary analogue secretory carcinoma (MASC) is a rare and recently described tumour of the salivary glands. MASC has similar histomorphological and immunohistochemical features of secretory carcinoma of the breast. MASC can be mistaken for other salivary gland tumours, especially acinic cell carcinoma. A 28-year-old man was diagnosed with a rare salivary gland tumour in Pretoria, South Africa (...