Neuroendocrine tumours comprise a small percentage of pancreatic neoplasia (10%) (1). Diagnosis of neuroendocrine tumours is difficult, especially if the tumours are small and nonfunctional. CT scans, MRI, and nuclear scans are sufficiently sensitive assessment tools for tumours with diameters of at least 2 cm; otherwise, the sensitivity and specificity of these techniques is less than 50% (2)....

Background: AChR antibodies (Abs) in Myasthnia Gravis (MG) are detected approximately 50% of ocular and 85% generalized MG by the current gold standard radioimmunoprecipitation assay (RIPA). Recently, fixed lived Cell-Based assays (L-CBA) developed. We clinically validated our in-house L-CBA detecting Ab suspected patients. Methods: Between January 2020 April 2022, we assayed 10167 sera for RIP...

Objectives. To investigate the presence of serum antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) in patients with myasthenia gravis (MG) analyze clinical characteristics prognostic factors associated MG. Methods. We retrospectively enrolled 363 MG analyzed follow-up data between positive negative for ANA anti-dsDNA. defined a Myasthenia Gravis Activities Daily Living (MG-AD...

BACKGROUND AND PURPOSE Myasthenia gravis (MG) is often categorized into thymoma-associated MG, early-onset MG with onset age <50 years, and late-onset MG with onset age ≥50 years. However, the boundary age of 50 years old between early- and late-onset MG remains controversial, and each category contains further subtypes. We attempted to classify MG from a statistical perspective. METHODS We a...

Bortezomib, an inhibitor of proteasomes, has been reported to reduce autoantibody titers and to improve clinical condition in mice suffering from lupus-like disease. Bortezomib depletes both short- and long-lived plasma cells; the latter normally survive the standard immunosuppressant treatments targeting T and B cells. These findings encouraged us to test whether bortezomib is effective for al...

The mucosal administration of the native antigen or peptide fragments corresponding to immunodominant regions is effective in preventing or treating several T cell-dependent models of autoimmune disease. No data are yet available on oral tolerance with immunodominant T-cell peptides in experimental autoimmune myasthenia gravis (EAMG), an animal model of B cell-dependent disease. We report that ...

We recently demonstrated that hepatic stellate cells induce the differentiation of myeloid-derived suppressor cells (MDSCs) from myeloid progenitors. In this study, we found that adoptive transfer of these MDSCs effectively reversed disease progression in experimental autoimmune myasthenia gravis (EAMG), a T cell-dependent and B cell-mediated model for myasthenia gravis. In addition to ameliora...

Objective This study aims to delineate the clinical phenotype of DSP-MG and assess histopathological correlation with thymoma. Background Double SeroPositive Myasthenia Gravis (DSP-MG), a rare autoimmune disease that affects neuromuscular transmission, is characterized by antibodies against both AChR MuSK receptors. second be conducted in world which attempts define patients. Design/Methods ret...

The Inter-American Court of Human Rights (IACrtHR) has developed in recent years an innovative jurisprudence that integrated the entity and extension States’ obligations regarding children’s rights—as established Article 19 ACHR—through evolutive, dynamic, effective interpretation American Convention on (ACHR). In fact, by acknowledging existence international corpus juris for protection rights...

Immunization of Lewis rats with acetylcholine receptor (AChR) purified from either Electrophorus electricus electric organ or syngeneic rat muscle induced experimental autoimmune myasthenia gravis (EAMG). This was demonstrated by clinical signs of weakness and by electromyographic evidence of imparied neuromuscular transmission. The amount of rat AChR required to induce an autoimmune response w...