The anticancer prodrug CPT-11 is a highly effective camptothecin analog that has been approved for the treatment of colon cancer. The 2.6 angstroms resolution crystal structure of its complex with Torpedo californica acetylcholinesterase (TcAChE) demonstrates that CPT-11 binds to TcAChE and spans its gorge similarly to the Alzheimer drug, Aricept. The crystal structure clearly reveals the inter...

Alzheimer is an age-dependent disease mostly with genetic origin. In this disorder, acetylcholine is decreased which results in deterioration of short-term memory. Many researches have been focused on finding new sources of medications with more potency and less side effects and investigating acetylcholinesterase inhibitors (AChEIs) has been the center of many researches. In the present study, ...

Acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) activities of lumbar ceresbrospinal fluid (CSF) from patients with a clinical or histological diagnosis of Alzheimer's disease have been compared with those of normal age-matched control patients and patients with dementia of non-Alzheimer aetiology. No significant differences in the AChE activity of lumbar CSF from histological...

BACKGROUND Rivastigmine is a carbamate drug designed to inhibit both acetylcholinesterase and butyrylcholinesterase by reversibly covalently bonding to these enzymes. Butyrylcholinesterase in-creases as Alzheimer disease progresses, so its inhibition may become more important as the disease worsens. Metabolism of rivastigmine occurs at the synapse rather than at the liver and previous studies h...

Using UV-visible spectrophotometric data of (1:1), electron donor-acceptor complexes (AD1, AD2 and AD3) have been investigated. The complexes concerned are n-butyl amine (D1) and cyclohexyl amine (D2) and phenyl hydrazine (D3) as electron donors with iron (III) ion as an electron acceptor (A) in methanol at 25°C. The values of formation constant (kAD), molar extinction coefficient (eAD), and ab...

Background and the purpose of the study: The amount of elder people who suffer from Alzheimer disease is continuously increasing every year. Cholinesterase inhibitors have shown to be effective in alleviating the symptoms of the disease, thus opening a field of research for these treatments. Herbal products, owning a reputation as effective agents in many biological studies are now drawing atte...

The growth response and biological activity of the cyanobacterium Oscillatoria sancta were investigated in starvation conditions. potential was examined on BG11 Zarrouk’s media. medium supported maximum test cyanobacterium. composition modified by excluding CaCl2·2H2O, NaCl, EDTA (Na), micronutrients, replacing sodium nitrate with urea. Using three different concentrations media (Treatments 1–3...