This paper presents simulation studies on the recovery of Acetonitrile from aqueous waste pharmaceutical processes. The focus is atmospheric distillation in two sequential columns to understand separation feasibility system; first column produces a distillate azeotropic composition, which mixed with fresh stream and fed second column, 99.9% pure residue. effect reflux ratio, reboiler duty flowr...

In the title compound, C8H6N2O3S, the dihedral angle between the nitro group and the benzene ring is 6.76 (9)°. The bond-angle sum at the S atom is 308.1°. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds to generate (010) sheets. The crystal studied was found to be a racemic twin.

The retention behaviors of various low-molecular-weight compounds in low-temperature HPLC with an ODS (octadecyl silica) column and liquid CO2 mobile phase containing methanol or acetonitrile as modifiers were investigated. addition methanol/acetonitrile reduced the xanthone, which was dominated by content, independent modifier. Additionally, polycyclic aromatic hydrocarbons (PAHs) methanol/ace...

(S)-Warfarin 7-hydroxylation and midazolam 1'-hydroxylation are among the preferred probe substrate reactions for CYP2C9 and CYP3A4/5, respectively. The impact of solvents on enzyme activity, kinetic parameters, and predicted in vivo hepatic clearance (Cl(H)) associated with each reaction has not been evaluated. The effects of increasing concentrations [0.1-2% (v/v)] of six organic solvents (ac...

Acetonitrile (methyl cyanide) is a common industrial organic solvent but is a rare cause of poisoning. We report the first recorded UK case. Acetonitrile is slowly converted to cyanide, resulting in delayed toxicity. We describe a case of deliberate self-poisoning by a 39-year-old woman resulting in cyanide poisoning 11 hours later which was successfully treated by repeated boluses of sodium ni...

Methods were developed for the analysis of acetonitrile and its metabolite cyanide in the blood of rats exposed to acetonitrile. Acetonitrile was analyzed by the headspace technique coupled to gas chromatography with detection by flame ionization, and cyanide was analyzed by high-performance liquid chromatography with fluorescence detection (lambdaex = 418 nm and lambdaem = 460 nm) after deriva...

An amperometric method was developed by using a lead working electrode in acetonitrile organic solution for detecting acetic acid. The mechanisms of electrochemical reaction were corresponding to the reduction of acetic ions in acetonitrile organic solution. The steady state amperometric current resulted from the reduction of acetic ions to produce the aldehyde in a two-electron process. In the...