Some of the diseases like ulcerative colitis, Crohn disease and certain types of intestinal cancers are not treatable effectively. Our aim was to investigate the protective effects of 2-aminoethyl diphenylborinate (2-APB) on the rats with acetic acid induced colitis. Twenty four Sprague-Dawley rats were randomly divided into the following four groups: (1) control group, (2) colitis group, (3) 2...

Previous studies have shown that ghrelin exhibits a protective and therapeutic effect in the gut. The aim of the present study was to examine whether administration of ghrelin affects the course of acetic acid-induced colitis and to determine what is the role of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in this effect. In sham-operated or hypophysectomized male Wistar rats, c...

This study aimed to evaluate the anti-inflammatory effects of Annona squamosa (A. squamosa) leaf aqueous extract against acetic acid induced colitis in rats with a trial to explore its use for the treatment of colon inflammation. Sprague Dawley rats weighing 180-200 g were used in this study. Treatment with A. squamosa extract at dose 300 mg/kg for 4 weeks counteracted acetic acid induced ulcer...

The effects of ketotifen, a 'mast cell stabiliser,' on two models of experimental colitis were examined. The inflammatory response elicited by either trinitrobenzene sulphonic acid or acetic acid resulted in increased colonic synthesis of platelet activating factor, prostaglandin E2, thromboxane B2, leukotrienes B4 and C4, and myeloperoxidase activity. Intragastric administration of ketotifen 1...

Triphala formulation is one of the renowned formulation used alone or along with other ingredients in Ayurvedic therapeutics for the treatment of gastro-intestinal problems including large intestinal inflammation and colitis. The purpose of the present study is to evaluate the role of one of the Triphala formulation called as Chinnodbhavadi kwath (decoction) in modulating the extent and severit...

BACKGROUND Inflammatory bowel disease (IBD) is characterized by most common symptoms such as rectal bleeding. Lack of specific, curative treatments tempted us to evaluate the therapeutic efficacy of quercetin against acetic acid induced IBD like symptoms. METHODS Animals were randomly divided into five groups (n = 6): naive, control, sulphasalazine and quercetin, and were pretreated for three...

scopes may cause chemical colitis [1–3]. However, it remains controversial whether the agent reponsible is the peracetic acid or the hydrogen peroxide in the solution. We recently encountered four cases of chemical colitis, showing characteristic morphologic and histologic features, including the “snow white sign”, following use of a new automated disinfection device in our endoscopy unit. The ...

Enhanced nitric oxide (NO) generation by stimulated NO synthase (NOS) activity may, through its oxidative metabolism contribute to tissue injury in experimental colitis. In this study the possible amelioration of experimental colitis by NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NOS activity, was evaluated. Colitis was induced in rats by intracolonic administration of 30 mg trin...

TEMPOL, a cyclic nitroxide stable radical blocks biological damage by breaking chain reactions through termination reaction with free radicals, and by inhibiting the catalytic effect of transition metals. This study tested its protective effect on two models of experimental colitis as free radicals play an important part in their pathogenesis. TEMPOL was given intragastrically immediately after...