N-acetylcysteine (NAC) is a drug  used  widely and effectively in oral  and  ‎intravenous  forms  as  a  specific  antidote  for acetaminophen poisoning.  In children ‎considering the toxic dose of acetaminophen ingested by the patient and the body weight, the ‎physician prescribes a specific dose of NAC. There is always a risk of  iatrogenic overdose of  ‎NAC  which can cause different mild to...

N-acetylcysteine (NAC) is a drug  used  widely and effectively in oral  and  ‎intravenous  forms  as  a  specific  antidote  for acetaminophen poisoning.  In children ‎considering the toxic dose of acetaminophen ingested by the patient and the body weight, the ‎physician prescribes a specific dose of NAC. There is always a risk of  iatrogenic overdose of  ‎NAC  which can cause different mild to...

Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year. Data from the U.S. Acute Liver Failure Study Group registry of more than 700 patients with acute liver failure across the United States implicates acetami...

BACKGROUND The long-term mortality of acetaminophen (APAP) poisoning has not yet been well studied; hence, we conducted this study to gain understanding of this issue. METHODS We conducted a nationwide population-based cohort study by identifying 3235 participants with APAP poisoning and 9705 participants without APAP poisoning in Taiwan between 2003 and 2012 in the Nationwide Poisoning Datab...

objective: to determine the epidemiology of acute childhood poisoning in shiraz, southern iran. methods: this was a prospective cross-sectional descriptive study, being performed in nemazee and dastgheib hospitals affiliated with shiraz university of medical sciences. the study included pediatric patients (<18 years) referred to our centers due to acute poisoning. demographic and etiological fa...

The immune system is alerted to cell death by molecules known as damage-associated molecular patterns (DAMPs). These molecules partly mediate acetaminophen-induced liver injury, an archetypal experimental model of sterile cell death and the commonest cause of acute liver failure in the western world. Cyclophilin A (CypA) is an intracellular protein that is proinflammatory when released by cells...

Acetaminophen overdose is common and can result from deliberate/nonstaggered or accidental/staggered ingestion. Patients presenting within 24 h of an acetaminophen overdose can safely be managed on medical wards. Early management of nonstaggered overdose is guided by the plasma acetaminophen concentration, whereas management of accidental/staggered ingestion is guided by ingested dose. Ingested...

In Mexico, more than 70 % of acute pediatric poisoning is caused by medicines. The age groups at greatest risk of drug poisoning are those between 2 to 5 years and 14 to 18 years; although in this last group, drug ingestion is usually intentional. The purpose of our study was to determine the frequency of unintentional drug poisoning in the pediatric population attended in a tertiary care hospi...

N-acetylcysteine (NAC) is used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. Here we report a rare case of iatrogenic NAC overdose following an error in preparation of the solution, and describe its clinical symptoms. Laboratory results and are presented and examined. A 23-year-old alert female patient weighing 65 kg presented to the em...

Deliberate self-poisoning presenting at Craigavon Area Hospital in 1991 was examined and compared to the years 1976 and 1986. Self-poisoning has not declined over the 15 year period 1976-1991. The reduction in the use of benzodiazepines, and increase in paracetamol, previously reported, continues. Possible reasons for this are examined, in relation to local and national drug prescribing.