BACKGROUND The Abraham general solvation model can be used in a broad set of scenarios involving partitioning and solubility, yet is limited to a set of solvents with measured Abraham coefficients. Here we extend the range of applicability of Abraham's model by creating open models that can be used to predict the solvent coefficients for all organic solvents. RESULTS We created open random fo...

The Influence of Books and Movies addiction to microbiology came early in my boyhood through books and film. First there was the novel Arrowsmith by sinclair Lewis. in the movie adaptation, actor ronald coleman dealt with bubonic plague and quickly became my scientific hero. throughout the years, my paperback copy of this novel has been loaned to many students. next, i became fascinated by paul...

The Flexner Report had its roots in the recognition in the mid-19th century that medical knowledge is not something fixed but something that grows and evolves. This new view of medical knowledge led to a recasting of the goal of medical education as that of instilling the proper techniques of acquiring and evaluating information rather than merely inculcating facts through rote memorization. Ab...

Roads, neurons, the Internet, social relationships, mycelia. Everywhere we look, we find complex networks. This has been the case since time immemorial. But only recently has technology allowed us to record the structure of these huge networks and use this information in decision making. Hyperlinking web pages together and ranking them based on network structure has already revolutionized the w...