BACKGROUND Autoimmune Addison's disease (AAD) is a rare, highly heritable autoimmune endocrinopathy. It is possible that there may be some highly penetrant variants which confer disease susceptibility that have yet to be discovered. METHODS DNA samples from 23 multiplex AAD pedigrees from the UK and Norway (50 cases, 67 controls) were genotyped on the Affymetrix SNP 6.0 array. Linkage analysi...

Axonal degeneration is a key initiating event in many neurological diseases. Focal lesions to axons result in a rapid disintegration of the perilesional axon by acute axonal degeneration (AAD) within several hours. However, the underlying molecular mechanisms of AAD are only incompletely understood. Here, we studied AAD in vivo through live-imaging of the rat optic nerve and in vitro in primary...

Homology searches indicate that Saccharomyces cerevisiae strain BY4741 contains seven redundant genes that encode putative aryl-alcohol dehydrogenases (AAD). Yeast AAD genes are located in subtelomeric regions of different chromosomes, and their functional role(s) remain enigmatic. Here, we show that two of these genes, AAD4 and AAD14, encode functional enzymes that reduce aliphatic and aryl-al...

Gastro-intestinal nematodes in ruminants, especially Haemonchus contortus, are a global threat to sheep and cattle farming. The emergence of drug resistance, and even multi-drug resistance to the currently available classes of broad spectrum anthelmintics, further stresses the need for new drugs active against gastro-intestinal nematodes. A novel chemical class of synthetic anthelmintics, the A...

Raquel Kuerten de Salles. Departamento de Nutrição. Centro de Ciências da Saúde. Universidade Federal de Santa Catarina. Campus Universitário Reitor João David Ferreira Lima, s/n. Trindade. 88040-900 Florianópolis-SC. Brazil e-mail: [email protected] Ferreira-Melo AP, Salles RK, Vieira FGK, Ferreira GM. Comparative analysis of height estimation methods in hospitalized adults and elders. Nutr Hos...

CONTEXT There has been a great deal of research on the comorbidity between alcohol abuse or dependence (AAD) and major depression (MD). However, it is unclear whether AAD increases the risk of MD or vice versa. OBJECTIVE To examine the associations between AAD and MD using fixed-effects modeling to control for confounding and using structural equation models to ascertain the direction of caus...

In the present work, the influences of temperature, solvent concentration and ultrasonic irradiation time were numerically analyzed on viscosity reduction of residue fuel oil (RFO). Ultrasonic irradiation was applied at power of 280 W and low frequency of 24 kHz. The main feature of this research is prediction and optimization of the kinematic viscosity data. The measured results of eighty-four...

calculate some thermodynamic properties of molten polymers including specific volume and isothermal compressibility (s.m. hoseini, physical chemistry & electrochemistry, 2 (2014) 56-65). this work extended that eos to predict the volumetric properties of some molten ethylene copolymers including ethylene/1-octene, ethylene/1-butene (xethylene equal to 0.8543 and 0.563), ethylene/propene. the ab...

The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201(+) melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also expressed in melanocytes. To gain information about immunoreactivity and self-tolerance to this antigen, we established a model using the murine tyrosinase-derived ...