نتایج جستجو برای: a8
تعداد نتایج: 1002 فیلتر نتایج به سال:
Those concerned ahout the treatment of women in public program8 have been eying the sociul security system from thi8 angle i% recent yeara. vUriOU8 prOpO8al8 for modifying the position Of working wives under the program and it8 provisions for famliy protection have been put forth. To help in U88e88ing such prOpO8Ul8, thts UrtiCIe reviews the program’s purpoaee, evolution, and general scope with...
The membrane protein bacteriorhodopsin (BR) can be kept soluble in its native state for months in the absence of detergent by amphipol (APol) A8-35, an amphiphilic polymer. After an actinic flash, A8-35-complexed BR undergoes a complete photocycle, with kinetics intermediate between that in detergent solution and that in its native membrane. BR/APol complexes form well defined, globular particl...
Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice
Neuroinflammation is a hallmark of Amyotrophic Lateral Sclerosis (ALS) in hSOD1G93A mouse models where microglial cells contribute to the progressive motor neuron degenerative process. S100-A8 and S100-A9 (also known as MRP8 MRP14, respectively) are cytoplasmic proteins expressed by inflammatory myeloid cells, including microglia macrophages. Mainly acting heterodimer, S100-A8/A9, when secreted...
ویروس موزائیک زرد کدو (ZYMV) از ویروسهای مهم کدوئیان است. پروتیین پوششی (Coat Protein, CP) پوتیویروسها به لحاظ تبارزایی حائز اهمیت است و از سوی دیگر منطقه ورامین نیز از مناطق مهم تولید کدوئیان بشمار میآید، اما تاکنون ناحیه ZYMV-CP در جدایههای این منطقه تعیین توالی نشده است. بنابراین، هدف این پژوهش، تعیین توالی ZYMV-CP در جدایه های ورامین و بررسی روابط فیلوژنتیکی آن با دیگر جدایههای ZYM...
Pichel et al., 1996; Sanchez et al., 1996; Schuchardt et We present genetic evidence that integrins regulate al., 1996). A number of transcription factors, including epithelial–mesenchymal interactions during organoWT-1, Pax-2, and BF-2, are also required for kidney genesis. Mice with a mutation in the a8 gene do not development (Kreidberg et al., 1993; Torres et al., 1995; express the integrin...
OBJECTIVE The S100 alarmins A8, A9, and A8/A9, secreted by activated neutrophils and monocytes/macrophages, are involved in the pathogenesis of various inflammatory diseases. S100A8/A9 has previously been linked to atherogenesis and cardiovascular (CV) disease. We investigated whether S100A8, A9, and A8/A9 correlate with carotid artery disease and CV risk in apparently healthy individuals. AP...
Botulism is a severe neurological disease caused by the complex family of botulinum neurotoxins (BoNT). Based on the different serotypes known today, a classification of serotype variants termed subtypes has been proposed according to sequence diversity and immunological properties. However, the relevance of BoNT subtypes is currently not well understood. Here we describe the isolation of a nov...
We have recently identified a mechanistic link between disruption of the microtubule cytoskeleton and inhibition of tumor angiogenesis via the hypoxia-inducible factor-1 (HIF-1) pathway. Based on this model, we hypothesized that other microtubule-targeting drugs may have a similar effect on HIF-1alpha. To test that hypothesis, we studied the effects of different clinically relevant microtubule-...
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