نتایج جستجو برای: a549 cells

تعداد نتایج: 1384602  

Journal: :Tropical Journal of Pharmaceutical Research 2022

Purpose: To investigate the anti-proliferative effect of pomolic acid on lung cancer cells (A549), and theunderlying mechanism.Methods: The viability acid-treated A549 was determined by MTT colony formation assays. Cell monitored with acridine orange/ethidium bromide (AO/EB) staining. Protein expressions Bax Bcl-2 were assayed western blotting.Results: Pomolic suppressed growth cells, an half-m...

Journal: :International journal of oncology 2011
Ryuji Ikeda Lee C Vermeulen Elim Lau Zhisheng Jiang Kamakshi Sachidanandam Katsushi Yamada Jill M Kolesar

Gemcitabine is an effective chemotherapy against non-small cell lung cancer (NSCLC). However, resistance to gemcitabine reduces its efficacy. We have isolated gemcitabine-resistant human non-small cell lung cancer A549 cells, termed A549/GR cells. A549/GR cells were resistant to gemcitabine as well as paclitaxel and docetaxel but not carboplatin and irinotecan. The expression level of multidrug...

2017
Lili Yang Chunjuan Du Lei Wu Jinpu Yu Xiumei An Wenwen Yu Shui Cao Hui Li Xiubao Ren

Background Cytokine-induced killer (CIK) cells can potentially enhance the tumor-killing activity of chemotherapy. Objective This study aimed to evaluate the effects of CIK cells on cisplatin (DDP) resistance in the human lung adenocarcinoma cell line A549/DDP. Methods The detect resistance index, drug resistance related-genes and cytokine secretion of A549/DDP co-cultured with CIK cells were a...

Journal: :Journal of pharmacological sciences 2010
Kenji Miki Hiromitsu Tanaka Yoko Nagai Chiwaka Kimura Masahiro Oike

We examined the effects of transforming growth factor beta(1) (TGFbeta(1)) on cellular functions in human lung cancer cell line A549. Treatment of A549 cells with 1 ng/ml TGFbeta(1) for more than 3 days altered their morphology from an epithelial cobblestone-like appearance to a fibroblast-like one, reduced the expression of E-cadherin mRNA and protein, and induced the formation of F-actin fibe...

2012
Kelly Jean Thomas Marty R. Jacobson

Evasion of apoptosis is implicated in almost all aspects of cancer progression, as well as treatment resistance. In this study, resistance to apoptosis was identified in tumorigenic lung epithelial (A549) cells as a consequence of defects in mitochondrial and autophagic function. Mitochondrial function is determined in part by mitochondrial morphology, a process regulated by mitochondrial dynam...

Journal: :Oncology Letters 2023

Gemcitabine is one of the most widely used chemotherapy drugs for advanced malignant tumors, including non‑small cell lung cancer. However, clinical efficacy gemcitabine limited due to drug resistance. The aim present study was investigate role p21 in gemcitabine‑resistant A549 (A549/G+) cancer cells. IC50 values were determined using a Cell Counting Kit‑8 (CCK‑8) assay. m...

2016
Xiongxiong Liu Chao Sun Bingtao Liu Xiaodong Jin Ping Li Xiaogang Zheng Ting Zhao Feifei Li Qiang Li

Non-small cell lung cancer (NSCLC) cells often possess a hypermethylated Keap1 promoter, which decreases Keap1 mRNA and protein expression levels, thus impairing the Nrf2-Keap1 pathway and thereby leading to chemo- or radio-resistance. In this study, we showed that genistein selectively exhibited a radiosensitizing effect on NSCLC A549 cells but not on normal lung fibroblast MRC-5 cells. Genist...

2017
Linrong Pang Jinger Lu Jia Huang Caihong Xu Hui Li Guangbo Yuan Xiaochun Cheng Jun Chen

The aim of the present study was to investigate the effects of microRNA (miR-)146a on the cisplatin sensitivity of the non-small cell lung cancer (NSCLC) A549 cell line and study the underlying molecular mechanism. The differences in expression of miRNAs between A549 and A549/cisplatin (A549/DDP) cells were determined, and miR-146a was selected to study its effect on cisplatin sensitivity of A5...

Journal: :Brazilian Archives of Biology and Technology 2022

HIGHLIGHTS Anticancer activities of ASE and DSE extracts were investigated. Angelica sylvestris have anticancer potential on HT-29 HeLa cells. Delphinium staphisagria A549 MCF-7 induce apoptosis cancer

2016
Mathias Schemmerer Silke Apelt Eva Trojnar Rainer G. Ulrich Jürgen J. Wenzel Reimar Johne

Hepatitis E virus (HEV) is a human pathogen with increasing importance. The lack of efficient cell culture systems hampers systematic studies on its replication cycle, virus neutralization and inactivation. Here, several cell lines were inoculated with the HEV genotype 3c strain 47832c, previously isolated from a chronically infected transplant patient. At 14 days after inoculation the highest ...

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