نتایج جستجو برای: a1298c

تعداد نتایج: 565  

Journal: :Genetics and molecular research : GMR 2013
Q Lv J Lu W Wu H Sun J Zhang

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected to evaluate the...

2013
Wenju Wang Zongliu Hou Chunhui Wang Chuanyu Wei Yaxiong Li Lihong Jiang

BACKGROUND Inconsistent results were reported in recent literature regarding the association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and the susceptibility of congenital heart disease (CHD). In this study, we performed a meta-analysis to investigate the associations by employing multiple analytical methods. METHODS Literature search was performed and pub...

Journal: :Genetics and molecular research : GMR 2016
S H Yildiz M Ozdemir Erdogan M Solak O Eser E S Arıkan Terzi B Eser V Kocabaş A Aslan

The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. In this study, the genotype distribution of the MTHFR gene A1298C polymorphism and the levels of serum homocystein...

2012
Shuyu Long Xingliang Yang Xiaojiao Liu Pei Yang

BACKGROUND The association between the methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and the susceptibility to cervical lesions was unclear. This study was designed to investigate their precise association using a large-scale meta-analysis. METHODS The previous 16 studies were identified by searching PubMed, Embase and CBM databases. The crude odds ratios and their co...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Xiang Tan Yong-Yong Wang Lei Dai Xu-Qiang Liao Ming-Wu Chen

BACKGROUND Associations between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and esophageal cancer risk have been reported in many articles recently, but results were controversial. Therefore the present meta-analysis was conducted to to provide a more precise estimation. METHODS Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of...

2010
Jadranka Vraneković Ivana Babić Božović Nada Starčević Čizmarević Alena Buretić-Tomljanović Smiljana Ristić Oleg Petrović Miljenko Kapović Bojana Brajenović-Milić

Understanding the biochemical structure and function of the methylenetetrahydrofolate reductase gene (MTHFR) provides new evidence in elucidating the risk of having a child with Down syndrome (DS) in association with two common MTHFR polymorphisms, C677T and A1298C. The aim of this study was to evaluate the risk for DS according to the presence of MTHFR C677T and A1298C polymorphisms as well as...

2017
Lilya M. Berkani Fadia Rahal Ines Allam Soraya Mouaki Benani Aïcha Laadjouz Reda Djidjik

Methotrexate (MTX) is the most used drug in rheumatoid arthritis (RA) treatment. However, it shows variability in clinical response, which is explained by an association with genetic polymorphisms. This study aimed to elucidate the role of the two gene polymorphism C677T and A1298C of the methylenetetrahydrofolate reductase (MTHFR) in response to MTX in Algerian RA patients. Study included 54 e...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Sabrina Narayanan Josie McConnell Julian Little Linda Sharp Chandrika J Piyathilake Hilary Powers Graham Basten Susan J Duthie

OBJECTIVE Homozygosity for variants of the methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased risk for colorectal cancer. We have investigated the relationships between two variants of the MTHFR gene (C677T and A1298C) and blood folate, homocysteine, and genomic stability (strand breakage, misincorporated uracil, and global cytosine methylation in lymphocytes) in a st...

Journal: :Arquivos brasileiros de endocrinologia e metabologia 2012
Adriana Lima Mello Selma Freire de Carvalho da Cunha Maria Cristina Foss-Freitas Helio Vannucchi

OBJECTIVE To determine plasma homocysteine levels during fasting and after methionine overload, and to correlate homocysteinemia according to methylenetetrahydrofolate reductase (MTHFR) polymorphism in type 2 diabetic adults. SUBJECTS AND METHODS The study included 50 type 2 diabetic adults (DM group) and 52 healthy subjects (Control group). Anthropometric data, and information on food intake...

2015
Antonia M. Fernández-Peralta Juan J. González-Aguilera

Varicose veins occur commonly in the general population but, MTHFR is an enzyme that is important in homocysteinemetabolism. despite much research, the etiology of venous disease is still poorly understood. The pathogenesis of the vein dilatation remains obscure in spite of the evidence of a primary defect in the vein wall. A number of epidemiological studies have shown that, in addition to env...

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