Background. Serial myocardial perfusion imaging with "'Tc-sestamibi (MIBI) was used to evaluate infarct risk area and salvage after thrombolysis. The purpose of this investigation was to determine whether changes in MIBI defect size observed after reperfusion may result in part from distortion of regional and global left ventricular geometry. Methods and Results. Twenty-five open-chest dogs wer...

introduction: various radiopharmaceuticals, including 67ga, 201tl, and 99mtc-sestamibi have been used to differentiate benign from malignant thyroid nodules. 99mtc-tetrofosmin, a lipophilic cationic radiotracer, and 99mtc-sestamibi have also been reported to accumulate in thyroid tumors. in this study, we evaluated the role of 99mtc-tetrofosmin in the differentiation of malignant from benign th...

we present a female patient with atypical chest pain who was referred to our department for ischemia evaluation. 99mtc-mibi myocardial perfusion scan with dipyridamole stress was performed. sub-diaphragmatic activity in the hepatic tissue and then in the bowel loops caused severe overlap on the inferior wall even on consecutive delayed images. dipyridamole stress was repeated for the patient wi...

Scintimammography is the functional imaging study of the breast with singlephoton radiopharmaceuticals, such as 99mTc-sestamibi or 99mTc-tetrofosmin. In 1994, Khalkhali et al. (1) reported the first series with a relatively large number of patients on the clinical application of scintimammography. In their group of 59 patients, in whom an abnormal mammogram and physical examination warranted bi...

BACKGROUND Increased 99mTc-sestamibi stress lung-to-heart ratio (sLHR) has been shown to predict cardiac outcomes similar to pulmonary uptake of thallium. Peak heart rate and use of pharmacologic stress affect the interpretation of lung thallium uptake. The current study was performed to determine whether 99mTc-sestamibi sLHR measurements are affected by stress-related variables, and whether th...

UNLABELLED Sustained myocardial ischemia with angina pectoris, electrocardiographic changes and subsequent non-Q-wave infarctions has been reported during percutaneous transluminal rotational atherectomy of complex coronary lesions. The purpose of this study was to evaluate the effect of rotational atherectomy on regional myocardial perfusion as assessed by serial 99mTc-sestamibi SPECT imaging ...

OBJECTIVE Our study evaluated the accuracy and reliability of 3 radiochemical purity (RCP) measurement methods of 99mTc-sestamibi. A regular-sized (1.0 cm x 9.0 cm) Whatman 31 ET Chr paper strip (regular 31 ET) also was included in our evaluation because of its ease in handling. METHODS The miniaturized and regular 31 ET methods were compared with the standard RCP testing method (aluminum oxi...

Objective The essential prerequisite for focused parathyroidectomy in patients with primary hyperparathyroidism (pHPT) is proper localization of all autonomic tissue. Sensitivity of conventional imaging modalities (ultrasound, 99mTc-sestamibi scintigraphy/SPECT/CT) is influenced by different factors (i.e., size/weight and position of autonomic tissue) and decreases in the presence of a multinod...

OBJECTIVE Chemical reactions involved in preparing 99mTc radiopharmaceuticals occasionally result in products of substandard purity. A retrospective examination of preparation problems that occurred in the author's institution was conducted to better define the incidence, recognize patterns and identify causes of substandard 99mTc radiopharmaceutical products. METHODS All 99mTc radiopharmaceu...

PURPOSE To test whether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) induce detectable signals in tumor cells and whether such signals may reveal alterations of the apoptotic program. EXPERIMENTAL DESIGN Tumor cells were treated with gefitinib or erlotinib and tested for their ability to accumulate 99mTc-Sestamibi, a radiolabeled lipophilic cation that localizes in...