99m The use of Tc-DTPA is for brain imaging renal flow study, and glomerular filtration rate measurement. Following intravenous injection, 99mTc-DTPA is rapidly cleared from the blood by glomerular filtration. Renal retention is 7% of the injected dose at 1 h and 95% is excreted within 24 h. It is neither secreted nor reabsorbed by the tubules and has negligible biliary excretion and eliminatio...

During the beginning of SARS-CoV-2 pandemic, there was a shortage masks and respirators for protection health care professionals. Masks noninvasive ventilation (NIV) in combination with viral-proof filters, worn by healthcare workers, could serve as an alternative measure. We determined simulated factor (SPF) such devices comparison to conventional surgical masks, N95, FFP3 respirators. were mo...

BACKGROUND In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMAA), chitosan, 1,4,7-triacyclononane-1,4,7-triacetic acid (NOTA), NOTA-super p...

Her technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA) radioaerosol inhalation lung scintigraphy (May 21, 2008) revealed marked hypoventilation of the left lung and retention of the radiotracer in the right peri-hilar region, suggestive of a parenchymal process. The use of 99mTC human albumin macroaggregates (99mTC MAA) revealed no perfusion in the left lung and perfusion defects in...

STUDY OBJECTIVES Paraquat, a widely used herbicide, has been shown to cause severe and often fatal pulmonary fibrosis in humans and laboratory animals. Although paraquat is known to be directly cytotoxic to lung parenchyma, changes in routine lung scintigraphy results after acute paraquat intoxication have not been reported. The objective of this project was to investigate changes in lung venti...

In order to improve on the technique of noninvasive detection of renal artery stenosis, we studied the effects of angiotensin converting enzyme inhibition with captopril on individual kidney hemodynamics and function as assessed by technetium-99m diethylenetriaminepentaacetic acid [( 99mTc]DTPA) renal flow studies and iodine-131 orthoiodohippurate [( 131I]hippuran) renography in experimental Go...

Gamma camera cisternography after intrathecal administration of 111In-DTPA is a widely used and well established technique for studies of cerebrospinal fluid (CSF) circulation. The radiation dose from 111In, however, is a limiting factor that sometimes seriously affects the image quality and, hence, correct interpretation. This investigation was designed to assess the value of tomographic techn...

UNLABELLED Glomerular filtration rate (GFR) is an important index of renal function. Twenty-four-hour creatinine clearance overestimates GFR in patients with poor renal function. Inulin and iothalamate clearances are accepted reference standards for determining GFR but are expensive and laborious. We have previously reported that GFRs obtained by measuring the disappearance of 99mTc-DTPA from u...

RATIONALE AND OBJECTIVES The purpose of this study was to evaluate the influence of hydration status upon renogram patterns and renal physiological parameters and clarify the differences between DTPA and MAG3 studies in normal volunteers. MATERIAL AND METHODS The study populations were 22 kidneys of 11 volunteers with no history of hypertension or renal disease with normal serum creatinine le...

OBJECTIVE Vincristine has been widely used in various chemotherapeutic protocols in oncology. The purpose of this study was to evaluate the effect of vincristine on the biodistribution of 99mTc-DMSA, 99mTc-GHA, and 99mTc-DTPA in Balb/c female mice. METHODS Vincristine (0.03 mg, 0.3 mL) was injected into female isogenic Balb/c mice (n = 15), in 3 doses over an interval of 96 h. The 99mTc-DMSA,...