Age (n = 805) 56.6 ± 16.5 59.3 ± 17.8 0.075 Gender (n = 805) 0.574 Male 408 (61.8%) 86 (59.3%) Colour/race (n = 805) 0.798 White 407 (61.7%) 88 (60.7%) Pardum 129 (19.1%) 30 (20.7%) Black 106 (16.1%) 21 (14.5%) Yellow 18 (2.7%) 6 (4.1%) Type of dialysis (n = 349) 0.748 Haemodialysis 239 (36.2%) 56 (38.6%) Peritoneal dialysis 46 (7.0%) 8 (5.5%) Immunosuppressive therapy (n = 803) 0.952 Yes 31 (4...

Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA methylation, play a role in these processes. This paper reviews the current state of knowledge of the involvement of C1 metabolism and methyl donors...

The objectives of this study were to determine the extent to which pH and ionic strength influence mu- and m-calpain activity and the inhibition of calpains by calpastatin. Calpastatin, mu-calpain, and m-calpain were purified from at-death porcine semimembranosus. Mu-calpain or m-calpain (0.45 U) were incubated with the calpain substrate Suc-Leu-Leu-Val-Tyr-7-amino-4-methyl coumarin in the pres...

We use Fourier domain optical coherence tomography (OCT) data to assess retinal blood oxygen saturation. Three-dimensional disk-centered retinal tissue volumes were assessed in 17 normal healthy subjects. After removing DC and low-frequency a-scan components, an OCT fundus image was created by integrating total reflectance into a single reflectance value. Thirty fringe patterns were sampled; 10...

Agnès Lillo-Le Louët1; Martine Wolf2; Lilia Soufir3; Arnaud Galbois4,5,6; Anne-Sylvie Dumenil2; Georges Offenstadt4,5,7; Meyer-Michel Samama8, 9 1AP-HP, European Hospital Georges Pompidou, Paris, France; 2AP-HP, Antoine Béclère Hospital, Clamart, France; 3Saint-Joseph Hospital, Paris, France; 4 AP-HP, Hôpital Saint-Antoine, Service de Réanimation Médicale, Paris, France; 5UPMC, Univ Paris 06, S...

BACKGROUND The combined use of anticoagulants, antiplatelet agents, and invasive coronary procedures reduces ischemic coronary events but also increases bleeding in patients with acute coronary syndromes. We therefore assessed whether fondaparinux would preserve the anti-ischemic benefits of enoxaparin while reducing bleeding. METHODS We randomly assigned 20,078 patients with acute coronary s...

The microsomal synthesis of docosahexaenoic acid (DHA) from radiolabeled eicosapentaenoic acid was tested in vitro using the livers of crab-eating monkeys. The test animals included 1 fetus (embryonic day 120), 2 neonates (full-term, embryonic day 165), and 2 adults. DHA was formed equally in the liver microsomes of each animal. Neonatal livers were found to contain higher percent of arachidoni...

VAc/BuA Copolymerization Reactor Myung-June Park, Mustafa T. Dokucu and Francis J. Doyle III* Department of Chemical Engineering, University of California Santa Barbara Santa Barbara, CA 93106, U. S. A. *To whom all correspondence should be addressed (Tel: (805) 893-8133, Fax: (805) 8934731, E-mail: [email protected])

Time-temperature-transformation (TTT) curves have been determined for SRL 165 waste glass. Extent and sequence of crystallization were determined by XRD and SEM. The incipient crystallization product, spinel, can be determined at one volume percent by magnetic susceptibility. The type and percentage of crystallization is correlated with waste glass durability. * The information contained in thi...