Objective: To evaluate the efficacy and safety of AbobotulinumtoxinA (ABO) dose escalation in correction moderate-to-severe glabellar lines. Design: Phase 2, 36-week, multicenter, randomized, dose-ranging, double-blind, placebo-controlled study. Methods: Adults with lines received a single ABO treatment, dosed at 50, 75, 100, or 125 U, placebo. Primary endpoint was week 4 composite ≥2-grade res...

The combination of Fe(OTf)2 with N-methyl bis(picolylamine) (Me-bpa) L7 enables epoxidation linear olefins including terminal, internal, and cyclic ones, using hydrogen peroxide as terminal oxidant under mild conditions. In the presence picolinic acid additive improved yields epoxides up to 75 % have been achieved.