Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection. Analysis of this pathway sugg...

In the present study, the feeding stage, body parts, development and sex specific activity of Glutathione S-transferases (GSTs) were observed in different mosquito species (Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi, An. culicifacies, An. annularis, An. subpictus, An. vagus). GST activity was assayed spectrophotometrically at 23°C, using a UV Max microplate Reader, to measure th...

Chronic pelvic pain is a common debilitating condition affecting women and presents a major challenge to healthcare providers. Laparoscopy is the only test capable of diagnosing peritoneal endometriosis and adhesions. Gynaecologists have, therefore, seen it as an essential tool in the assessment of women with chronic pelvic pain. This article explores the role of surgery in the management of ch...

The subject of this essay is the dialectic between word and thought. Between the word and the thought there is therefore no priority of one over the other, but mutual presupposition and a perpetual overlapping: it is at this level that the link between word and thought is actually affected by creativity. Between thought and word there has always implicitly been an original complicity that makes...

Wen-shin Lee* ([email protected]), Mathematics and Computer Science Department, University of Antwerp, Middelheimlaan 1, 2020 Antwerpen, Belgium. Symbolic-Numeric Sparse Polynomial Interpolation. We consider the problem of sparse interpolation of a multivariate polynomial that is given as a black box in floating-point arithmetic. When the target polynomial is sparse, there are efficient inte...

The Ebers Papyrus provides evidence that the Egyptians used plants containing cardioactive steroids (CASs) at least 3000 years ago. However, it was not until 1785, when William Withering wrote the first systemic account about the effects of the foxglove plant, that the use of CASs was more widely accepted into the Western apothecary. Foxglove, the most common source of plant CAS, was initially ...

The problem of adaptive stochastic airline seat inventory control lies at the heart of airline revenue management. This problem concerns the allocation of the finite seat inventory to the stochastic customer demand that occurs over time before the flight is scheduled to depart. The objective is to find the right combination of customers of various fare classes on the flight such that revenue is...