نتایج جستجو برای: 55212

تعداد نتایج: 98  

Journal: :Journal of medicinal chemistry 1998
J Y Shim E R Collantes W J Welsh B Subramaniam A C Howlett M A Eissenstat S J Ward

The present study describes the implementation of comparative molecular field analysis (CoMFA) to develop two 3D-QSAR (quantitative structure-activity relationship) models (CoMFA models 1 and 2) of the cannabimimetic (aminoalkyl)indoles (AAIs) for CB1 cannabinoid receptor binding affinity, based on pKi values measured using radioligand binding assays that displace two different agonist ligands,...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Sun Hee Kim Seok Joon Won Xiao Ou Mao Catherine Ledent Kunlin Jin David A Greenberg

Cannabinoids, acting through the CB1 cannabinoid receptor (CB1R), protect the brain against ischemia and related forms of injury. This may involve inhibiting the neurotoxicity of endogenous excitatory amino acids and downstream effectors, such as nitric oxide (NO). Cannabinoids also stimulate neurogenesis in the adult brain through activation of CB1R. Because NO has been implicated in neurogene...

2004
arco Pistis Simona Perra Giuliano Pillolla Miriam Melis Anna Lisa Muntoni Gian Luigi Gessa

ackground: Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by xposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) ystem, involved in the processing of drug-induced reward, is a locus of action of cannabinoids and endocannabinoids. Thus, we ompared the effe...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
Pattipati S Naidu Steven G Kinsey Tai L Guo Benjamin F Cravatt Aron H Lichtman

Although cannabinoids are efficacious in laboratory animal models of inflammatory pain, their established cannabimimetic actions diminish enthusiasm for their therapeutic development. Conversely, fatty acid amide hydrolase (FAAH), the chief catabolic enzyme regulating the endogenous cannabinoid N-arachidonoylethanolamine (anandamide), has emerged as an attractive target for treating pain and ot...

Journal: :basic and clinical neuroscience 0
alireza komaki neurophysiology research center, hamadan university of medical sciences, hamadan, iran nasrin hashemi-firouzi neurophysiology research center, hamadan university of medical sciences, hamadan, iran. shiva shojaie department of physiology, school of medicine, hamadan university of medical sciences, hamadan, iran zobin souri department of physiology, school of medicine, hamadan university of medical sciences, hamadan, iran somayeh heidari department of physiology, school of medicine, hamadan university of medical sciences, hamadan, iran siamak shahidi neurophysiology research center, hamadan university of medical sciences, hamadan, iran.

introduction: previous studies have shown that cannabinoidergic system is involved in anxiety. however, there are controversial reports in the experimental studies. the aim of this study is to evaluate the effect of pharmacological stimulation or blocking of cb1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (epm) test in rat. the epm is o...

Alireza Komaki, Nasrin Hashemi-Firouzi, Shiva Shojaie, Siamak Shahidi, Somayeh Heidari, Zobin Souri,

Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...

2000
PAUL L. PRATHER NANCY A. MARTIN CHRISTOPHER S. BREIVOGEL STEVEN R. CHILDERS

Previous studies had shown that the amplification factors for cannabinoid receptors, defined as the number of total G proteins activated per occupied receptor, differs between several rat brain regions. In this study, we sought to determine which specific Gi/Goa subunits were activated by CB1 receptors in several rat brain regions and if this coupling might explain the regional differences in r...

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