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Endothelins (ETs), 21-amino-acid peptides involved in the pathogenesis of various diseases, bind to ET(A) and ET(B) receptors to initiate their effects. Based on the same core structure, we have developed four small-molecule ET receptor antagonists, ABT-627, ABT-546, A-182086 and A-192621, which exhibit difference in selectivity for ET(A) and ET(B) receptors. In this report, we compare the pote...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 188 6.4 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285 9.7 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282 9.6 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171 5.8 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

In a 10-year prospective study, 561 displaced subcapital fractures of the femoral neck in 546 patients were treated with the Hastings bipolar hemiarthroplasty. Within six months of their operations, 148 patients had died. In 322 hips followed up, 243 with adequate serial radiographs separated by more than one year, only 14 (5.6%) showed acetabular erosion. A group of 91 had been reviewed for be...

Jean Guard, D.V.M., Ph.D. 21 Veterinary Medical Officer 22 U. S. Department of Agriculture 23 Agricultural Research Service 24 950 College Station Rd. 25 Athens, GA 30605 USA 26 TEL: 706-546-3446 27 FAX: 706-546-3035 28 EMAIL: [email protected] 29 30 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Appl. Environ. Microbiol. doi:10.1128/AEM.00852-12 AEM Accepts, pu...

EARLY STUDIES ON EGG DISINFECTION M. E. BERRANG' USDA, ARS, PPMQRU, Russell Research Center, Athens, GA 30604-5677 Phone: (706) 546-3551 F M : (706) 546-3633 E-mail: [email protected] N. A. COX USDA, ARS, PMSRU, Russell Research Center, Athens, GA 306045677 J. E FRANK Univmity of Georgia, Food Science and Technology, Athens, GA 30602 R J. BUHR USDA, ARS, PPMQRU, Russell Resemh Center, Athens, G...

INTRODUCTION Type I interferons (IFNs) are implicated in the pathogenesis of systemic sclerosis (SSc). MEDI-546 is an investigational human monoclonal antibody directed against the type I IFN receptor. This Phase 1 study evaluated the safety/tolerability, pharmacokinetics (PK), immunogenicity, and pharmacodynamics (PD) of single and multiple intravenous doses of MEDI-546 in adults with SSc. M...

The research context of this article is the recognition and description of dynamic textures. In image processing, the wavelet transform has been successfully used for characterizing static textures. To our best knowledge, only two works are using spatio-temporal multiscale decomposition based on tensor product for dynamic texture recognition. One contribution of this article is to analyse and c...

Light sensing by photoreceptors controls phototropism, chloroplast movement, stomatal opening, and leaf expansion in plants. Understanding the molecular mechanism by which these processes are regulated requires a quantitative description of photoreceptor dynamics. We focus on a light-driven signal transduction mechanism in the LOV2 domain (LOV, light, oxygen, voltage) of the blue light photorec...