PURPOSE To investigate changes in the area of the foveal avascular zone (FAZ) in patients with retinal vascular disease. PATIENTS AND METHODS This retrospective, consecutive study examined 53 eyes of 53 patients with macular edema due to branch retinal vein occlusion in 25 patients (47.2%) and nonproliferative diabetic retinopathy in 28 patients (52.8%). The macular edema was treated with an ...

The aim of this study was to determine whether there is superior diagnostic accuracy for the detection and exclusion of bronchiectasis using 16-slice CT of the chest (1 mm) compared with conventional high-resolution CT (HRCT) of the chest (10 mm). A prospective study was carried out in patients who were referred for chest CT by a chest physician for the investigation of bronchiectasis over a 1-...

Hepatectomy is the treatment of choice for patients with resectable colorectal carcinoma metastases. However, recurrences occur in about half to two-thirds of the patients after surgery. To reduce the recurrence rate, it is important to isolate those factors that influence intrahepatic recurrence. In this study, we assessed histopathological factors associated with intrahepatic recurrences in 5...

wilson’s disease (wd) or hepato-lenticular degeneration is a rare autosomal-recessive disorder. a prevalence rate of 30 cases per million and a birth incidence rate of one per 30,000 to 40,000 are often quoted. in 40 to 50% of individuals with wd, hepatic dysfunction is the initial clinical manifestation. with the exception of liver transplantation, treatment of wd is only palliative and intend...

The 53-kDa glycoprotein and sarcalumenin (160-kDa glycoprotein) were extracted from rabbit skeletal muscle sarcoplasmic reticulum with EGTA and purified by fractionation on DEAE-Sephadex A-25 and lentil lectin-Sepharose 4B. Sarcalumenin was shown to bind up to 400 nmol of Ca2+/mg of protein at pH 7.5, which is equivalent to binding of approximately 35 mol of Ca2+/mol of protein. The apparent di...

The interactions of HIV-1 reverse transcriptase (HIV-1 RT) with a synthetic 53/19-mer DNA substrate was investigated. For this template-primer HIV-1 RT displayed a Km value of 20 nM. The 53/19-mer competitively inhibited DNA synthesis performed on poly (rC).oligo(dG) with Ki value of 260 nM. This corresponded well to an equilibrium dissociation constant (Kd) of 300 nM, as determined by analytic...

PURPOSE The objectives of this study are (1) to measure concordance of tumor position on breath-hold (BH) computed tomography (CT) scans relative to the natural tumor path during free breathing (FB) and (2) to evaluate the benefits of the breathing monitoring device Abches (Apex Medical, Tokyo) for stereotactic ablative radiotherapy (SABR) treatment planning. METHODS In 53 lung cancer patient...

Spectral properties of sign symmetric matrices are studied. A criterion for sign symmetry of shifted basic circulant permutation matrices is proven, and is then used to answer the question which complex numbers can serve as eigenvalues of sign symmetric 3 × 3 matrices. The results are applied in the discussion of the eigenvalues of QM -matrices. In particular, it is shown that for every positiv...

We consider classes of models related to those introduced by Lehmann in 1953 and Sklar in 1959. Recently developed algorithms for finding profile NP likelihood procedures are discussed, extended and implemented for such models by combining them with the MM algorithm. In particular we consider statistical procedures for a regression model with proportional expected hazard rates, and for transfor...