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Dysregulation of microRNAs has been implicated in many cardiovascular diseases including fibrosis. Here we report that miR-433 was consistently elevated in three models of heart disease with prominent cardiac fibrosis, and was enriched in fibroblasts compared to cardiomyocytes. Forced expression of miR-433 in neonatal rat cardiac fibroblasts increased proliferation and their differentiation int...
BACKGROUND ............................................................................................................... 433 Statistical Thermodynamic Quantities ...................................................................... 433 Protoco& f Molecular Simulation ........................................................................... 435 The Free Energy Problem .........................
Pancreatic β cell dysfunction is a key characteristic in the pathogenesis of diabetes mellitus (DM). MicroRNAs (miRNAs) have been identified to serve a role in DM pathogenesis, but how specific miRNAs regulate glucose‑stimulated β cell functions remain unclear. The present study aimed to explore the effects of miR‑433 on cell growth under high‑glucose culture conditions and to determine the pos...
Background: Previous studies found miRNAs can play important role in the pathogenesis, metastasis and prognosis of hepatocellular carcinoma by regulating the expression of its target genes. We evaluated the clinical significance of miRNA-433 expression in hepatocellular carcinoma. Method: We collected 28 primary hepatocellular carcinoma specimens matched by 28 normal paracarcinoma tissues. The ...
Pneumolysin is one of the family of thiol-activatable, cytolytic toxins. Within these toxins the amino acid sequence Trp-Glu-Trp-Trp is conserved. Mutations made in this region of pneumolysin, residues 433-436 inclusive, did not affect cell binding or the formation of toxin oligomers in the target cell membrane. However, the mutations did affect haemolysis, leakage of low-molecular-mass metabol...
INTRODUCTION................................................................ 427 MATERNAL-FETAL INCOMPATIBILITY.............................................. 427 DISEASES OF THE GASTROINTESTINAL TRACT .... .................................. 430 RHEUMATIC FEVER ............................................................ 432 POLIOMYELITIS ............................................................
There’s a broad field of applications for the microcontroller technology, that can be enumerated from simple, like small electric equipment operation, until sophisticated, like single loop digital controllers with man-machine and machine-machine interface, also using complex digital control techniques. The main preoccupation for us is to transmit to an undergraduate student, who hadn’t had any ...
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