28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity with MIC value of 15.6 to 31.3 μg/mL against 55 S. aureus isolates (43 MRSA and 12 MSSA isolates)....

Different clinical presentations and prognoses have been implied between pancreatic head and body/tail cancers. We aimed to identify the prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC). Thirty-two pairs of patients with strictly matched early stage (II) pancreatic head and body/tail cancers were enrolled. The molecular ...

Motivated by the recent discovery of a hierarchical X-ray flaring phenomenon in Mrk 421, we conducted a systematic search for X-ray flares from Mrk 501, another well-known TeV blazar, by making use of the rich RXTE archival database. We detected flares over a wide range of timescales, from months down to minutes, as in the case of Mrk 421. However, the flares do not seem to occur nearly as freq...

We discuss an effect of the intergalactic absorption of the TeV γ-rays in time-averaged spectrum of Mkn 501 measured by the HEGRA collaboration. Analysis of the spectral behavior, variability time scale and relevant calculations of TeV γ-ray emission allow to conclude the presence of a noticeable absorption of the TeV γ-rays in the Mkn 501 energy spectrum.

TeV gamma rays from the blazar Markarian 501 have been detected with the University of Durham Mark 6 atmospherič Cerenkov telescope using the imaging technique at large zenith angles. Observations were made at zenith angles in the range 70 • − 73 • during 1997 July and August when Markarian 501 was undergoing a prolonged and strong flare.

0747-5632/$ see front matter 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.chb.2013.02.002 ⇑ Corresponding author. Tel.: +1 501 569 3552; fax: +1 501 569 3547. E-mail addresses: [email protected] (M.P. McCreery), [email protected] (P.G. Schrader), [email protected] (S.K. Krach), [email protected] (R. Boone). Michael P. McCreery a,⇑, P.G. Schrader , S. Kathleen Krach ...

High risk of cardiovascular diseases caused by existing PPAR-γ agonists such as rosiglitazone and pioglitazone has been recently reported. CKD-501 is a novel selective PPAR-γ agonist as a potential target to reduce cardiovascular risk in non-insulin dependent diabetes mellitus (NIDDM). In this study, We investigated potential cardiotoxicity of CKD-501 and compared its toxicity with that of rosi...