99% of all deaths in childbirth are in the least developed countries. Annually, 45 million women deliver without a skilled birth attendant, a situation in which the greatest number of maternal deaths occur. In many low-resource settings, having enough skilled birth attendants remains a distant goal. The commonest single cause of maternal death is from post-partum haemorrhage, from which one wom...

1Department of Obstetrics and Gynaecology, Queen Alia Military Hospital, Royal Medical Services, Amman, Jordan (Correspondence to M.I. Al-Taani: [email protected]). ABSTRACT To assess the effectiveness of intravaginal misoprostol for second trimester uterine evacuation, we studied 70 women with singleton pregnancies complicated by fetal malformation or dead fetuses. Participants received 200 μ...

In this study, in order to find novel biologically active pyrazole oxime compounds, a series of pyrazole oxime derivatives containing a 5-trifluoromethylpyridyl moiety were synthesized. Preliminary bioassays indicated that most title compounds were found to display good to excellent acaricidal activity against Tetranychus cinnabarinus at a concentration of 200 μg/mL, and some designed compounds...

Background: Current study was conducted to compare the efficacy of tab Misoprostol 50 microgram by oral and sublingual routes for induction labour. Methods: A randomised comparative labour in 200 cases pregnant women at term were divided into two groups 100 each µg route repeated 4 hourly either or until an adequate contraction pattern set (establishment 3 uterine contractions a period 10 minut...

PURPOSE To investigate the ability of a commercial extract from the medicinal plant Artemisia annua to modulate production of the cytokine, tumor necrosis factor-alpha (TNF-α), and the cyclooxygenase (COX) inflammatory marker, prostaglandin E2 (PGE2) in activated neutrophils. METHODS Neutrophils were harvested from rat whole blood and cultured in the presence of plant extract or control sampl...

Osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are three common types of arthritis which are routinely treated with NSAIDs. Guidelines and data regarding the treatment of these three diseases will be briefly discussed. The American College of Rheumatology (ACR) in 1995 published guidelines for the medical management of OA which were updated in 2000 [1–3]. In thes...

A simple and robust method using high-performance liquid chromatography with UV detection was developed and validated for the determination of six pyrrole-imidazole (PI) polyamides (HN.49, TGF-β1f, TGF-β1t, HN.50f, HN.50t, and LOX-1) in rat plasma. After the plasma proteins were precipitated with methanol containing phenacetin as an internal standard, the analytes were separated on a Luna C18 (...

The antidepressant drug amitriptyline hydrochloride was obtained in a dry powder form and was screened against 253 strains of bacteria which included 72 Gram positive and 181 Gram negative bacteria and against 5 fungal strains. The minimum inhibitory concentration (MIC) was determined by inoculating a loopful of an overnight peptone water culture of the organism on nutrient agar plates containi...

OBJECTIVE This prospective randomized controlled study was carried out with the purpose of assessing the efficacy of sublingual misoprostol in decreasing intraoperative blood loss and the need for additional uterotonic agents at cesarean delivery. METHODS One hundred seventy-four women undergoing elective or emergency cesarean delivery were assigned randomly to receive either 400 μg misoprost...