Recently there has been increased interest in high nitrogen content “green” energetic materials which are designed to produce relatively non-toxic decomposition products as part of a push to decrease the environmental impact of energetic materials through all phases of their existence. With the use of a T-Jump/Time-of-Flight Mass Spectrometer (T-Jump/TOFMS) capable of high heating rates (up to ...

The results of geometry optimisation of possible Watson-Crick-like pairs of 2,6-diamino-4-oxy-5-formamidopyrimidine (fapy-adenine) or 4,6-diamino-5-formamidopyrimidine (fapy-guanine) were presented. In the absence of the external field the fapy-adenine is able to form pairs with all four canonical nucleic acid bases. However, pairs with guanine, cytosine and thymine the most stable are. Thus, t...

1-alkyl aryl-5-amino-4-(cyanoformimidoyl)imidazoles 4 were reacted with malononitrile and 2-amino-1,1,3-propenetricarbonitrile under mild experimental conditions, which led to 5-amino-3-(substituted benzyl)-6,7-dicyano-3H-imidazo[4,5-b]pyridines 5 and 6,8-diamino-3-(4-substituted benzyl)-3H-imidazo[4,5-b]-1,8-naphthyridine-7,9-dicarbonitrile 6, respectively, when the reaction was carried out in...

2-Amino-5-nitro-6-ribitylamino-4(3H)-pyrimidinone (7) was phosphorylated with chlorophosphoric acid yielding an isomer mixture containing about 63% of the 5'-phosphate 7a together with other monophosphates and bisphosphates of 7. Preparative HPLC afforded pure 7a. Catalytic hydrogenation of 7a yields the labile substrate of pyrimidine deaminase, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-...

The Arabidopsis thaliana open reading frame At4g20960 predicts a protein whose N-terminal part is similar to the eubacterial 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate deaminase domain. A synthetic open reading frame specifying a pseudomature form of the plant enzyme directed the synthesis of a recombinant protein which was purified to apparent homogeneity and was shown by NMR s...

Amiloride (AM), N-amidino-3,5,-diamino-6-chloropyrazinamide hydrochloride, induces natriuretic effects without potassium loss or rise in serum uric acid. 1 , 4 In single doses, AM has been shown to be less potent than hydrochlorothiazide (He); however, when administered daily in approximately maximal dosage, the natriuretic action of AM is sustained for a longer period so that the negative sodi...

Fapy-adenine, Fapy-guanine, Tautomerism, Solvent Effect The results of theoretical geometry prediction of formamidopyrimidine(fapy)-adenine and fapy-guanine tautomers are presented. Among 54 potential tautomeric structures of fapyadenine the most stable structure corresponds to the diamino-keto isomer. The solvent effect has insignificant influence on the fapy-adenine tautomers succession. The ...