Pigment biosynthesis in the cyanobacterium, Anacystis nidulans, was examined in the presence of gabaculine (5-amino-1,3-cyclohexadienyl-carboxylic acid). At 20 micromolar, this inhibitor blocked the biosynthesis of both chlorophyll and phycocyanin. Analogs of gabaculine were not effective as inhibitors of chlorophyll or phycocyanin biosynthesis. Iron- and phosphate-deficient cultures were 2- to...

BACKGROUND Pain during and after topical photodynamic therapy (PDT) is one of the few severe adverse effects of the new treatment of skin diseases. OBJECTIVE To compare the pain experienced in normal skin treated with 5-aminolevulinic acid (ALA) PDT and 5-aminolevulinic methylester (ALA-ME) PDT. DESIGN Double-blind randomized trial. INTERVENTIONS Twenty healthy volunteers were treated ran...

this study was aimed to investigate the effects of environmental pollution with heavy metals from ferro-nickel smelter on aminolevulinic acid dehydratase (alad) activity, and to analyze the blood lead level of feral pigeon ( columba livia ) in ferro-nickel smelter courtyard in drenas city, republic of kosovo. for this purpose, twenty specimens of feral pigeon (20 birds, males and females), were...

In Escherichia coli, Pseudomonas aeruginosa, and Achromobacter metalcaligenes gamma-aminolevulinic acid synthase and gamma-aminolevulinic acid dehydratase appear to be the rate limiting enzymes of porphyrin and heme biosynthesis. Bypassing of these enzymes by addition of gamma-aminolevulinic acid or porphobilinogen results in overproduction of tetrapyrroles.