نتایج جستجو برای: 5 علمالنفس

تعداد نتایج: 1215767  

Journal: :Current opinion in cell biology 2013
Li Shen Yi Zhang

5-Methylcytosine (5mC) can be converted to 5-hydroxymethylcytosine (5hmC) in mammalian cells by the ten-eleven translocation (Tet) family of dioxygenases. While 5mC has been extensively studied, we have just started to understand the distribution and function of 5hmC in mammalian genomes. Despite the fact that this new epigenetic mark has only been discovered three years ago, exciting progress ...

2010
Daniel Globisch Martin Münzel Markus Müller Stylianos Michalakis Mirko Wagner Susanne Koch Tobias Brückl Martin Biel Thomas Carell

5-Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian tissue at so far controversial levels. The function of the modified base is currently unknown, but it is certain that the base is generated from 5-methylcytosine (mC). This fuels the hypothesis that it represents an intermediate of an active demethylation process, which could involve further oxidation of the hydr...

Journal: :Evidencia, actualizacion en la práctica ambulatoria 2002

Journal: :NeuroImage 2006
Dietmar Cordes Rajesh R Nandy

A new method based on an autoregressive noise model of order 1 is introduced to the problem of detecting the number of components in fMRI data. Unlike current information-theoretic criteria like AIC, MDL, and related PPCA, which do not incorporate autocorrelations in the noise, the new method leads to more consistent estimates of the model order, as illustrated in simulated and real fMRI restin...

2008
Jerold L. Weiss Krishna R. Pattipati Alan S. Willsky John S. Eterno John T. Crawford

A decentralized failure detection and isolation (FDI) methodology, which is robust with respect to model uncertainties and noise, is presented. Redundancy metrics are developed, and optimization problems are posed for the choices of robust parity relations. Closed-form solutions for some special failure cases are given. Connections are drawn with other disciplines, and the use of the metrics to...

Journal: :Chemical communications 2016
Hao-Ying Zhang Jun Xiong Bao-Ling Qi Yu-Qi Feng Bi-Feng Yuan

We developed a novel strategy by oxidation-derivatization combined mass spectrometry analysis for the determination of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA. We reported the presence of 5-formylcytosine in RNA of mammals and found that ascorbic acid and hydroquinone can increase the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in DNA and RNA.

Journal: :Nucleic acids research. Supplement 2002
Takeshi Wada Tomomi Shimazaki Shingo Nakagawa Takashi Otuki Shinya Kurata Tsutomu Suzuki Kimitsuna Watanabe Kazuhiko Saigo

Recently, novel taurine-containing uridine derivatives were discovered in mammalian mitochondrial tRNAs, and these modified ribonucleosides existed at the first position of the anti-codon. This paper describes the chemical synthesis of these novel uridine derivatives, 5-taurinomethyluridine (tau m5U) and 5-taurinomethyl-2-thiouridine (tau m5s2U). These taurine-containing uridine derivatives wer...

2015
Marta W. Szulik Pradeep S. Pallan Boguslaw Nocek Markus Voehler Surajit Banerjee Sonja Brooks Andrzej Joachimiak Martin Egli Brandt F. Eichman Michael P. Stone

I our recently published article on the structures and base pair opening dynamics of Dickerson−Drew dodecamer (DDD) duplexes with incorporated 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), or 5-carboxylcytosine (5caC), we inadvertently failed to reference two publications by others who had reported structures of the DDD with single 5hmC residues inserted per strand. Spingler and co-wo...

Journal: :Organic & biomolecular chemistry 2014
Seiichiro Kizaki Hiroshi Sugiyama

Tet family proteins have the ability to convert 5-methylcytosine (mC) to 5-hydroxymethylcytosine, and further to 5-formylcytosine and 5-carboxycytosine. We found that CGmCGCG can be the substrate of Tet protein, and observed iterative oxidation of mC by HPLC analysis. We also demonstrated that Tet protein favours single-stranded DNA over double-stranded DNA.

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