نتایج جستجو برای: 497
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Cyclin E1, encoded by the CCNE1 gene, promotes G1/S transition, chromosome instability, and oncogenesis. Here, we show that miR-497 and miR-34a target the 3'-UTR of CCNE1. miR-497 and miR-34a are downregulated in cancer cells and their ectopic expression inhibited cell proliferation and colony formation in vitro, and inhibited tumor growth in a xenograft model. The effect of simultaneous overex...
Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its phosphorylation at serine 1179 (eNOS-Ser(1179) in bovine sequence), which is associated with increased risk of vascular diseases. Here, we investigated the acute (<24 h) effect of arseni...
What is not so obvious is that the health of the poor is harmed in proportion to the size of the gap between rich and poor. It isn't the absolute level of poverty that matters so much as the size of the gap between rich and poor. In other words, "...what matters in determining mortality and health in a society is less the overall wealth of that society and more how evenly wealth is distributed....
Abstract There is a need for blood biomarkers meningioma. The role of circulating micro RNA in cancer diagnosis has been the objective several studies. One extensively studied miRNA different types microRNA-497 (miR-497). This study systematically evaluated miR-497 as meningioma biomarker disease and classification. We exosomal serum 74 samples (WHO grade I=25, WHO II=25, III=24), 53 healthy co...
Organophosphorus compounds are potent neurotoxic chemicals that are widely used in medicine, industry, and agriculture. The neurotoxicity of these chemicals has been documented in accidental human poisoning, epidemiological studies, and animal models. Organophosphorus compounds have 3 distinct neurotoxic actions. The primary action is the irreversible inhibition of acetylcholinesterase, resulti...
" Wir mssen wissen, wir werden wissen " (We must know, we shall know) Pr[Y ≥ ∆] = Pr[exp(tY) ≥ exp(t∆)] ≤ E [exp(tY)] exp(t∆) , the first part follows by the fact that exp(·) preserve ordering, and the second part follows by the Markov inequality. Observe that E [exp(tX i)] = 1 2 e t + 1 2 e −t = e t + e −t 2 = 1 2 1 + t 1! + t 2 2! + t 3 3! + · · · + 1 2 1 − t 1! + t 2 2! − t 3 3! + · · · = 1 ...
Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level. It has been proposed that miRNAs may be crucial to the modulation of the function of semaphorins. Previous findings have proven that miR-497-5p is upregula...
Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered by deregulated expression or function of several genes which contribute to multidrug resistance (MDR). MicroRNAs are ...
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