Human epidermal growth factor receptor 2 (HER2 or ErBb2) is a receptor tyrosine kinase overexpressed in 20-30% of breast cancers and associated with poor prognosis and outcome. Dysregulation of several microRNAs (miRNAs) plays a key role in breast cancer progression and metastasis. In this study, we screened and identified miRNAs dysregualted in HER2-positive breast cancer cells. Our molecular ...

polymorphism of the b-lactoglobulin (b-lg) gene in 101 cows belonging to the holstein herd and a superior cow, producing more than 150 kg milk/day, together with four offsprings was investigated by the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. in the holstein herd, the alleles a and b of the b-lg gene had frequencies of 0.53 and 0.47, respectively. th...

Total synthesis of spider toxins HO-416b (1) and Agel-489 (2) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. In this strategy, the C-N bonds were constructed by alkylation of sulfonamides with alkyl halides or Mitsunobu reaction with the corresponding alcohol. Beginning with monoprotection of the symmetrical diamine, the construction o...

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (includ...

This work present several advances in the understanding of dynamic data structures in the bit-probe model: • We improve the lower bound record for dynamic language membership problems to Ω(( lg n lg lg n ) ). Surpassing Ω(lg n) was listed as the first open problem in a survey by Miltersen. • We prove a bound of Ω( lg n lg lg lg n ) for maintaining partial sums in Z/2Z. Previously, the known bou...

By k-disturbed sequence we mean a sequence obtained from a sorted sequence by changing the values of at most k elements. We present an algorithm for single-hop radio networks that sorts a k-disturbed sequence of length n (where each station stores single key) in time 4n+ k · (⌈lg k⌉+⌈lg(n−k+1)⌉+6⌈lg k⌉)−2 with energetic cost 3·⌈ (⌈lg k⌉+1)(⌈lg k⌉+2) 2⌊n/k⌋ ⌉+ 4 · ⌈ ⌈lg k⌉ ⌊n/k⌋ ⌉+ 10. If (⌈lg k...

Previous studies have described the existence of high mobility group (HMG)-like proteins in macronuclei of the ciliated protozoan, Tetrahymena thermophila (Hamana, K., and K. Iwai, 1979, J. Biochem. [Tokyo], 69:1097-1111; Levy-Wilson, B., M. S. Denker, and E. Ito, 1983, Biochemistry, 22:1715-1721). In this report, two of these proteins, LG-1 and LG-2, have been further characterized. Polyclonal...