Bioactive glasses have been shown to stimulate osteogenesis both in vivo and in vitro. However, the molecular mechanisms underlying this process are still poorly understood. In this study, we have investigated the behaviour of osteoblast-like cells (MG63), cultured in the presence of bioglass particles. Three types of granules were used: 45S5 bioactive glass, 45S5 granules preincubated in tris ...

This study aimed to investigate bone responses to a novel bioactive fully crystallized glass-ceramic of the quaternary system P(2)O(5)-Na(2)O-CaO-SiO(2) (Biosilicate®). Although a previous study demonstrated positive effects of Biosilicate® on in vitro bone-like matrix formation, its in vivo effect was not studied yet. Male Wistar rats (n = 40) with tibial defects were used. Four experimental g...

Abstract Although the initial in vitro dissolution of bioactive glasses (BAG) is well characterized, long-term behaviour crystallized BAG scaffolds a continuous fluid flow incompletely understood. A detailed understanding vital for predicting their clinical applications. Here, we explored and reaction mechanisms partly crystalline glass–ceramic based on S53P4 45S5 using flow-through method Tris...

The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption the bone surrounding implant and improve osseointegration, respectively. However, presence pores as well poor adherence brittle behavior inherent glassy affect service implants from these samples. Therefore, they need be optimized. In this work,...

This study was to evaluate the acid-buffering capacity and antibacterial properties of orthodontic adhesives containing bioactive glasses (BAGs) (45S5, 45S5F, S53P4), Hydroxyapatite, beta-tricalcium phosphate, Canasite. Fillers comprising 15 wt% glasses, HAp, β-TCP, Canasite incorporated with 55 silanated glass were added a mixture UDMA/TEGDMA. Acid-buffering tested by exposing disc-shaped samp...

Bioactive glass formed on the base sample (Go) of 45S5 system with fluorine additives samples were prepared by melt quenching method. The glassy samples were subjected to DTA for determining temperatures at which phase transition occur. FTTR spectroscopy shed a light on the sorts of compounds, their structure as well as their functional groups. The crystalline nature of samples was confirmed by...