0

249 words Text: 4411 words. 3 Tables 2 Figures Page 1 of 30 Diabetes Care Diabetes Care Publish Ahead of Print, published online August 12, 2013 ABSTRACT: OBJECTIVE: Progressive decrease in the glomerular filtration rate (GFR), or renal decline, in type 1 diabetes (T1D) is seen in patients with macroalbuminuria. However, it is unknown whether this decline begins during microalbuminuria (MA) or ...

A 51-year-old man was referred for therapy of a submucosal tumor of the sigmoid colon. The lesion had been diagnosed during screening colonoscopy, and biopsies had shown gastrointestinal stromal tumor (GIST). We confirmed a 15-mm submucosal tumor located in the proximal sigmoid colon (●" Fig.1). Endoscopic full-thickness resection was performed with the Full Thickness Resection Device (FTRD; Ov...

The (+)-anti enantiomer of benzo[a]pyrene-7,8-dihydrodiol-9, 10-epoxide (BPDE) is a potent mutagenic and carcinogenic metabolite of benzo[a]pyrene (BP), and a major fraction is conjugated with glutathione in vivo. The chemopreventive role of glutathione S-transferases (GSTs) in protecting against covalent modification of DNA and other cellular macromolecules by BPDE was modeled in human T47D an...

ownloade pose: Notch signaling has been implicated to play a critical role in the tumorigenesis of neuroblas(NB) and can modulate calreticulin (CRT) expression that strongly correlates with tumor differenand favorable prognosis of NB. We thus sought to determine how Notch regulates CRT expression ffects NB tumor behavior. erimental Design: The Notch-dependent regulation of CRT expression in cul...

Hypertranscription and temporal expression from the Autographa californica nuclear polyhedrosis (AcNPV) baculovirus polyhedrin promoter involves an alpha-amanitin-resistant RNA polymerase and requires a trans-acting viral factor(s). We previously reported that a 30-kDa host factor, polyhedrin promoter binding protein (PPBP), binds with unusual affinity, specificity, and stability to the transcr...