Parfenova, Helena, John Haffner, and Charles W. Leffler. Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells. Am. J. Physiol. 277 (Cell Physiol. 46): C728–C738, 1999.— Nigericin decreases intracellular pH (pHi) and stimulates prostanoid (PG) synthesis in endothelial cells from cerebral microvessels of newborn pigs. Nigericin-induced PG produc...

Clancy, J. S., H. Takeshima, S. L. Hamilton, and M. B. Reid. Contractile function is unaltered in diaphragm from mice lacking calcium release channel isoform 3. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1205–R1209, 1999.—Skeletal muscle expresses at least two isoforms of the calcium release channel in the sarcoplasmic reticulum (RyR1 and RyR3). Whereas the function of RyR...

Hu, Ying-Li, Song Li, John Y.-J. Shyy, and Shu Chien. Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1593–H1599, 1999.—The disruption of microtubules by treating bovine aortic endothelial cells with 1027–1025 M colchicine caused apoptosis, as evidenced by DNA laddering and TdT-mediated dUTP nick e...

Schwartz, Gary J., Andrew Whitney, Chris Skoglund, Thomas W. Castonguay and Timothy H. Moran. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-Areceptors. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1144– R1151, 1999.—Adult Otsuka Long-Evans Tokushima fatty (OLETF) rats lack functional cholecystokinin A (CCK-A) receptors, are dia...

Ahrén, Bo, and Peter J. Havel. Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells). Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R959–R966, 1999.—The effect of leptin on insulin secretion is controversial due to conflicting results in the literature. In the present study, we incubated insulinproducing rat insulinoma INS-1 cells...

Wang, Jinjuan, and James C. Rose. Developmental changes in renal renin mRNA half-life and responses to stimulation in fetal lambs. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1130–R1135, 1999.—In the perinatal period there is increased renin gene expression in the kidney compared with other stages of development. This may be related to changes in responsiveness of the renin...

Wu, Xiao Chun, Peter J. Harris, and Edward J. Johns. Nitric oxide and renal nerve-mediated proximal tubular reabsorption in normotensive and hypertensive rats. Am. J. Physiol. 277 (Renal Physiol. 46): F560–F566, 1999.—In Inactin-anesthetized Wistar rats with an intact renal innervation, intratubular nitro-L-arginine methyl ester (L-NAME, 1024 M) increased proximal fluid uptake (Jva, at 2.47 6 0...

Nagayama, Takahiro, Takayuki Matsumoto, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, and Susumu Satoh. Role of cholinergic receptors in adrenal catecholamine secretion in spontaneously hypertensive rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1057–R1062, 1999.—We investigated the role of nicotinic and muscarinic receptors in secretion of catechol...

Burness, Gary P., Scot C. Leary, Peter W. Hochachka, and Christopher D. Moyes. Allometric scaling of RNA, DNA, and enzyme levels: an intraspecific study. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1164–R1170, 1999.—The activities of oxidative and glycolytic enzymes show body size-dependent relationships across a wide variety of taxa; however, the mechanistic basis remains ...

Merrill, David C., Jeffrey L. Segar, Oliva J. McWeeny, and Jean E. Robillard. Sympathetic responses to cardiopulmonary vagal afferent stimulation during development. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1311–H1316, 1999.—Previous work in our laboratory has demonstrated impairment of cardiopulmonary reflex control of renal sympathetic nerve activity (RSNA) during the newborn period. T...