Copper complexes with potent anti-tumor effect have been extensively developed. Most investigations of their modes of action focused on the biomolecular targets but not the signal transduction between target binding and cell death. We have previously shown that the cytotoxic complex pyridine(2,4-dihydroxybenzaldehyde dibenzyl semicarbazone)copper(II) (complex 1) shows selective binding to human...

Abstract New N2O2 type Schiff base has been designed and synthesized by condensing 2,4 dihydroxy benzaldehyde and α-naphthylamine in ethanol. Solid metal complexes of the schiff base with Cu(II), Ni(II) and Zn(II) metal ion were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis and ‘H NMR spectral studies. The data shows that the c...

During the screening of natural antioxidants from culture broths fungi mushroom origin, broth Polyporus parvovarius was found to exhibit potent antioxidant activity. An antioxidative substance, compound 1, isolated by solvent partitioning and column chromatography, its chemical structure determined nuclear magnetic resonance spectroscopic methods be 3,4-dihydroxybenzaldehyde. Compound 1 exhibit...

This study aims at determining the potentials of cinnamon (Cinnamomun burmannii) extracts to improve health-promoting properties white chocolate. LC-HRMS analysis was employed obtain information regarding phytochemical content while phosphomolybdenum, FRAP and DPPH assays were used determine antioxidant activity extract. Furthermore, extract loaded into nanoparticles before adding it The result...

Granulosa cells form ovarian follicles and play important roles in the growth and maturation of oocytes. The protection of granulosa cells from cellular injury caused by oxidative stress is an effective therapy for female infertility. We here investigated an effective bioactive compound derived from Prunus mume seed extract that protects granulosa cells from hydrogen peroxide (H2O2)-induced apo...

A highly simple, rapid, sensitive and selective method is developed for spectrophotometric determination of gabapentin in pure form as well as in pharmaceutical formulations. The method is based on the formation of a yellow Schiff base derived from the condensation of gabapentin drug (1-amino methyl) cyclo hexane acetic acid and 2,5-dihydroxybenzaldehyde (DHBA) exhibiting a maximum absorbance a...

In therapeutic interventions associated with melanin hyperpigmentation, tyrosinase is regarded as a target enzyme as it catalyzes the rate-limiting steps in mammalian melanogenesis. Since many known agents have been proven to be toxic, there has been increasing impetus to identify alternative tyrosinase inhibitors, especially from natural sources. In this study, we investigated 900 extracts fro...