Courses of antituberculous chemotherapy are more prolonged than ever, and the problem of the unpleasant side effects of the administration of para-aminosalicylic acid (PAS) harasses both patient and physician for longer periods of time. Clinicians who manage tuberculosis are quite familiar with the difficulties entailed in keeping an appreciable number of their patients on an uninterrupted, pro...

BACKGROUND Many advances have been recently made focused on the valuable help of dietary polyphenols in chronic inflammatory diseases. On the other hand, current treatment options for intestinal bowel disease patients are unsatisfying and, for this reason, it is estimated that many patients use dietary supplements to achieve extra benefits. AIM The aim of this work was to analyze under a mech...

The antibacterial properties of poly(N-acryloyl-4- and -5-aminosalicylic acids) and their borate complexes were evaluated. Poly(N-acryloyl-4- and 5-aminosalicylic acids) were used to render the antibiotics streptomycin and gentamicin insoluble. The antibacterial properties of the resultant water-insoluble streptomycin and gentamicin derivatives were evaluated, and the results show that the poly...

We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured i...

BACKGROUND & AIMS Activation of NF-kappaB/Rel has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Various drugs used in the treatment of IBD, such as glucocorticoids, 5-aminosalicylic acid, and sulfasalazine, interfere with NF-kappaB/Rel signaling. The aim of this study was to define the molecular mechanism by which sulfasalazine inhibits NF-kappaB activation. METHODS...

5-aminosalicylic acid (5-asa) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-nsa) in acidic media. in this work, electrolytic reduction of 5-nsa in alkaline media is presented. reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the ph for isolation of product are investigated. the yiel...