Biologically active heterocyclic compounds comprise of largest & manifold family organic compounds. These include Quinolines, Quinazolines, Aminoquinolines, etc and their derivatives. They exhibit multi-faceted biological properties like analgesic, anti-inflammatory, anticonvulsant, antibacterial, antifungal, antidepressant, anticancer, antitubercular &antihistaminic. are considered to ...

4AQR 4-Aminoquinoline retinopathy 4AQs 4-Aminoquinolines (chloroquine and hydroxychloroquine) ABW Actual body weight APC Antigen presenting cell BCVA Best corrected visual acuity C Chloroquine C p G ODN C p G oligodeoxynucleotide CV Color vision CYP Cytochrome P450 enzymes DFE Dilated fundus examination DNA Deoxyribonucleic acid ERK Extracellular signal-regulated kinases FP Ferriprotoporphyrin ...

4AQR 4-Aminoquinoline retinopathy 4AQs 4-Aminoquinolines (chloroquine and hydroxychloroquine) ABW Actual body weight APC Antigen presenting cell BCVA Best corrected visual acuity C Chloroquine C p G ODN C p G oligodeoxynucleotide CV Color vision CYP Cytochrome P450 enzymes DFE Dilated fundus examination DNA Deoxyribonucleic acid ERK Extracellular signal-regulated kinases FP Ferriprotoporphyrin ...

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have signi...